韓京

學位與職稱：博士，副教授

專業：藥物化學

研究方向：新葯分子的設計與合成、多肽類藥物研發

教育經歷

2004.09-2008.06 中國藥科大學 藥學院 製藥工程專業 學士

2008.09-2013.06 中國藥科大學 藥學院 藥物化學專業 博士

工作經歷

2018.07至今 江蘇師範大學副教授

2017.10-2018.10 University of Copenhagen（丹麥）訪問學者

2014.02至今 江蘇師範大學任教

2013.07-2014.01 連雲港市食品藥品監督管理局 主管藥師

近年來主要從事小分子及多肽類新葯分子的設計、合成及活性研究，糖尿病及肥胖領域的新葯篩選，此外在藥用新材料方向也開展了部分工作。近幾年在藥學領域頂尖期刊J. Med. Chem.,Euro. J. Med. Chem.,Brit. J. Pharmacol.,Biochem. Pharmacol.等發表SCI論文20餘篇，其中以第一作者及通訊作者身份發表論文15篇，授權發明專利2項。

主持的主要科研項目

1. 具有降糖和減肥雙重作用的新型多肽的設計、合成及生物活性研究，國家自然科學基金，主持

2. 新型降糖多肽及其納米緩釋製劑的設計、合成生物活性研究，江蘇省自然科學基金，主持

3. 長效化胰高血糖素樣肽-1衍生物的合成及生物活性研究，江蘇省教育廳，主持

發表的代表性論文

1.Jing Han*, Yingying Fei, Feng Zhou, Xinyu Chen, Ying Zhang, Lin Liu, Junjie Fu. Xenopus GLP-1 derived and PEGylated GLP-1 receptor agonists: long-acting hypoglycemic and insulinotropic activities with potential therapeutic utilities.British Journal of Pharmacology, 2018, 175, 544-557.

2.Jing Han*, Yue Huang, Xinyu Chen, Feng Zhou, Yingying Fei, Junjie Fu. Rational design of dimeric lipidatedXenopusglucagon-like peptide 1 analogues as long-acting antihyperglycaemic agents.European Journal of Medicinal Chemistry, 2018, 157, 177-187.

3.Jing Han*, Xinyu Chen, Liming Zhao, Junjie Fu, Lidan Sun, Ying Zhang, Feng Zhou, Yingying Fei. Lithocholic acid-based peptide delivery system for an enhanced pharmacological and pharmacokinetic profile ofXenopusGLP-1 analogs.Molecular Pharmaceutics, 2018, 15, 2840-2856.

4.Jing Han*, Feng Zhou, Yingying Fei, Xinyu Chen, Junjie Fu, Hai Qian. Preparation and pharmaceutical characterizations of lipidated dimericXenopusglucagon-like peptide-1 conjugates.Bioconjugate Chemistry, 2018, 29, 390-402.

5.Jing Han*, Yue Huang, Xinyu Chen, Feng Zhou, Yingying Fei, Junjie Fu. Lipidation and conformational constraining for prolonging the effects of peptides:Xenopusglucagon-like peptide 1 analogues with potent and long-acting hypoglycemic activity.European Journal of Pharmaceutical Sciences, 2018, 123, 111-123.

6.Jing Han*, Yiyun Wang, Qinghua Meng, Guangchao Li, Fangmin Huang, Su Wu, Yingying Fei, Feng Zhou, Junjie Fu. Design, synthesis and biological evaluation of PEGylatedXenopusglucagon-like peptide-1 derivatives as long-acting hypoglycemic agents.European Journal of Medicinal Chemistry, 2017, 132, 81-89.

7.Jing Han*, Yingying Fei, Feng Zhou, Xinyu Chen, Weiwei Zheng, Junjie Fu. Micellar nanomedicine of novel fatty acid modifiedXenopusglucagon-like peptide-1: improved physicochemical characteristics and therapeutic utilities for type 2 diabetes.Molecular Pharmaceutics, 2017, 14, 3954-3967.

8.Jing Han*, Xinyu Chen, Yiyun Wang, Yingying Fei, Feng Zhou, Ying Zhang, Lin Liu, Pengbin Si, Junjie Fu.XenopusGLP-1-inspired discovery of novel GLP-1 receptor agonists as long-acting hypoglycemic and insulinotropic agents with significant therapeutic potential.Biochemical Pharmacology, 2017, 142, 155-167.

9.Jing Han, Lidan Sun, Xun Huang, Zheng Li, Chenyu Zhang, Hai Qian, Wenlong Huang. Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability.British Journal of Pharmacology, 2014, 171, 5252-5264.

10.Jing Han, Lidan Sun, Yingying Chu, Zheng Li, Dandan Huang, Xiaoyun Zhu, Hai Qian, Wenlong Huang. Design, Synthesis, and Biological Activity of Novel Dicoumarol Glucagon-like Peptide-1 Conjugates.Journal of Medicinal Chemistry, 2013, 56, 9955-9968.

11.Jing Han, Xun Huang, Lidan Sun, Zheng Li, Hai Qian, Wenlong Huang. Novel Fatty Chain-modified Glucagon-Like Peptide-1 Conjugates with Enhanced Stability and Prolonged in vivo Activity.Biochemical Pharmacology, 2013, 86, 297-308.