李娜

1994-1998年，北京大學化學學院工作。

1999-2000年，美國堪薩斯大學葯化系CDDR博士后。

2000年，北京大學化學學院工作。

研究領域和興趣

主要研究方向為光學感測新原理、新方法。

光學感測新原理、新方法。主要興趣為：基於金屬納米材料光譜（熒光、局域表面等離子體共振吸收/散射）的生物感測，以及生物大分子與小分子的相互作用。

具有納米層間結構固定相的合成、酶及其他分子的固定化及其應用於分離以及光學感測器的研究等。生物大分子（蛋白質，核酸，糖類物質等）與小分子的超分子作用及其在生物大分子測定方面的應用研究。

口腔保健產品臨床功能的實驗室評價方法的建立及實施，如牙膏和潔牙劑的摩擦力及物理和化學清潔力的國際標準的建立和評價，與齲齒病相關的牙釉質脫礦和再礦化程度的定量測定方法的建立等。臨床數據的統計處理。

著作

● ● Quantitative Chemical Analysis(英文).北京大學出版社，2009(主編)（海外發行World Scientific Publishing Co Pte Ltd,2013）。

● ● 分析化學I（電子課件）.北京大學出版社,2007(主編)。

● ● 分析化學教程學習指導.北京大學出版社,2006(參編)。

● ● 分析化學教程.北京大學出版社,2005(參編)。

● ● 超越分子前沿.科學出版社，2004(參譯)。

● ● 2011年北京市高等教育精品教材。

論文

1. Tian Li, Xi Wu, Guangyu Tao, Haoyan Yin, Junlong Zhang, Feng Liu,Na Li*

A simple and non-amplification platform for femtomolar DNA and microRNA detection by combining automatic gold nanoparticle enumeration with target-induced strand-displacement.

Biosens. Bioelectron. 2018, 105, 137-142.

2. Xiaojing Pei, Tiancheng Lai, Guangyu Tao, Hu Hong, Feng Liu,Na Li*

Ultra-specific multiplexeddetection of low-abundance single-nucleotide variants by combining masking tactic with fluorescent nanoparticle counting.

Anal. Chem.2018,90, 4226-4233.

3. Xiaojing Pei, Haoyan Yin, Tiancheng Lai, Junlong Zhang, Feng Liu, Xiao Xu*,Na Li*

Multiplexed Detection of Attomole Nucleic Acids Using Fluorescent Nanoparticle Counting Platform

Anal. Chem.2018, 90, 1376-1383.

4. Guangyu Tao, Yang Chen, Ruoyun Lin, Jiang Zhou, Xiaojing Pei, Feng Liu,Na Li

How G-quadruplex topology and loop sequences affect optical properties of DNA-templated silver nanoclusters

Nano Res.2017, 11,223-2247.

5. Ruoyun Lin, Guangyu Tao, Yang Chen, Mingxing Chen, Feng Liu,Na Li*.

Constructing a robust fluorescent DNA-stabilized silver nanocluster probe module by attaching a duplex moiety

Chem. Eur. J.2017,23, 10893-10900.

6. Runyun Lin, Chenxi Li, Yang Chen, Feng Liu,Na Li*

Metal-enhanced fluorescence in biosensing applications, "Surface Plasmon Enhanced, Coupled and Controlled Fluorescence",2017, Edited by Geddes, C. D., Wiley, NJ. (Invited chapter).

7. Wu, Xi, Tian Li, Guangyu Tao, Ruoyun Lin, Xiaojing Pei, Feng Liu,Na Li.

Universal and Enzyme-Free Immunoassay Platform for Biomarker Detection Based on Gold Nanoparticle Enumeration with a Dark-Field Microscope.

Analyst,2017, 142, 4201-4205.

8. Tian Li, Xi Wu, Feng Liu,Na Li*.

Analytical Methods Based on the Light-Scattering of Plasmonic Nanoparticles at the Single Particle Level with Dark-Field Microscopy Imaging.

Analyst,2017, 142, 248-256.

9. Chenxi Li, Yixin Li, Yang Chen, Ruoyun Lin, Tian Li, Feng Liu,Na Li*

Modulating the DNA strand-displacement kinetics with the one-sided remote toehold design for differentiation of single-base mismatched DNA.

RSC Adv. 2016, 6, 74913-74916.

10. Yang Chen, Guangyu Tao, Ruoyun Lin, Xiaojing Pei, Feng Liu, Na Li*

Pre-Incubation of Auric Acid with DNA Is Unnecessary for the Formation of DNA-Templated Gold Nanoclusters

Chem.-an Asian J.2016,11, 1677-1681.

11. Tian Li, Xiao Xu, Guoqing Zhang, Ruoyun Lin, Yang Chen, Chenxi Li, Feng Liu, Na Li*

Nonamplification Sandwich Assay Platform for Sensitive Nucleic Acid Detection Based on Aunps Enumeration with the Dark-Field Microscope

Anal. Chem. 2016,88, 4188-4191.

12. Xiao Xu, Tian Li, Zhongxing Xu, Hejia Wei, Ruoyun Lin, Bin Xia, Feng Liu, Na Li*

Automatic enumeration of gold nanomaterials at single particle level

Anal. Chem.2015,87, 2576-2581.

13. Hongduan Huang, Hejia Wei, Mingjian Zou, Xiao Xu, Bin Xia*, Feng Liu, Na Li*

Modulating fluorescence anisotropy of terminally labeled dsDNA via the interaction between dye and nucleotides for rational design of DNA-recognition based applications

Anal. Chem.2015, 87, 2748-2754.

14. Zhenpeng Zhou, Tian Li, Hongduan Huang, Yang Chen, Feng Liu, Chengzhi Huang,*Na Li*

A dual amplification strategy for DNA detection combining bio-barcode assay and metal-enhanced fluorescence modality.

Chem. Commun.2014,50, 13373-13376.

15. Chenxi Li, Yixin Li, Xiao Xu, Xinyi Wang, Yang Chen, Xiaoda Yang, Feng Liu, Na Li*

Fast and quantitative differentiation of single-base mismatched DNA by initial reaction rate of catalytic hairpin assembly.

Biosens. Bioelectron.2014,60,57-63.

16. Zhenpeng Zhou, Hongduan Huang, Yang Chen, Feng Liu, Chengzhi Huang, Na Li*

A distance-dependent metal-enhanced fluorescence sensing platform based on molecular beacon design

Biosens. Bioelectron. 2014, 52, 367-373.

17. Xinyi Wang, Mingjian Zou, Hongduan Huang, Yuqian Ren, Limei Li, Xiaoda Yang, Na Li*

Gold nanoparticle enhanced fluorescence anisotropy for the assay of single nucleotide polymorphisms (SNPs) based on toehold-mediated strand-displacement reaction

Biosens. Bioelectron.2013,41, 569-575.

18. Xiao Xu, Yang Chen, Hejia Wei, Bin Xia, Feng Liu, Na Li*

Counting Bacteria Using Functionalized Gold Nanoparticles as the Light-Scattering Reporter

Anal. Chem.2012,84, 9721-9728.

19. Mingjian Zou, Yang Chen, Xiao Xu, Hongduan Huang, Feng Liu,Na Li*

The homogeneous Fluorescence Anisotropic Sensing of Salivary Lysozyme Using the 6-carboxy fluorescein-labeled DNA Aptamer.

Biosens. Bioelectron.2012,32, 148-154.

從1994年參加分析化學實驗、儀器分析實驗、高等分析實驗教學，以及定量化學分析課教學。現主講定量化學分析。