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李娟

四川大學生命科學院教授

李娟:女,四川大學生命科學院副教授。研究內容:“下丘腦-垂體-靶器官”作用通路,是調節動物生長發育的主要途徑。李娟博士目前在國家自然科學基金, 國家高科技研究計劃(863),轉基因新品種培育專項支持下,以家雞為研究模型,關注“下丘腦-垂體-卵巢”通路,圍繞催乳素生成釋放機制,卵泡發育機制開展受體功能鑒定與基因網路調控解析。第七屆大學生《挑戰杯》課外學術活動競賽:代表香港大學獲特等獎2008, 2011年度四川大學青年骨幹教師獎。代表性論文16篇。

人物經歷


學習與工作經歷:
1990-1994:四川大學,理學學士。
1994-1997:四川大學,理學碩士。
1997-1999:成都生物製品研究所,實習研究員。
1999-2003:香港大學動物學系,理學博士。
2004-2006:香港大學動物學系, 博士后。
2006-現在:四川大學生命科學院。

主要貢獻


研究內容

“下丘腦-垂體-靶器官”作用通路,是調節動物生長發育的主要途徑。李娟博士目前在國家自然科學基金, 國家高科技研究計劃(863),轉基因新品種培育專項支持下,以家雞為研究模型,關注“男下丘腦-垂體-卵巢”通路,圍繞催乳素生成釋放機制,卵泡發育機制開展受體功能鑒定與基因網路調控解析。

主要研究論文

1. Huang G, Li Juan*, Fu H, Yan Z, Bu G, He X, Wang Y. Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants. Domestic Animal Endocrinology (on line: DOI:10-1016/ j.domaniend. 2012.01.005), 2012 (* 通迅作者)。
2. Wang Y, Huang G, Li Juan, Meng F, He X. Leung F.C . Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology, 348: 270-280, 2012。
3. Wang Y, Wang CY, Wu Y, Huang G, Li Juan, Leung F C. Identification of the Receptors for Prolactin-releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens. Endocrinology 153, p1-14 (DOI: 10.1210/en.2011-1719), 2012。
4. Wang Y, Li Juan, Kwok AHY, Ge W & Lueng FC. A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative Endocrinology 166: 200-210, 2010。
5. Wang Y, Li Juan, C. Wang CY, Kwok AHY, Zhang X & Leung FC. Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38: 13-31, 2010。
6. Wang J, Wang Y, Li X, Li Juan* and Leung FC. Cloning, tissue distribution and functional characterization of chicken glucagon receptor. Poultry Science 87:2678-2688, 2008 (*通訊作者)。
7. Li Juan, Wang X, and Leung FC. The intragenomic polymorphism of a partially inverted repeat (PIR) in Gallus gallus domesticus, potential role of inverted repeats in satellite DNAs evolution. Gene 387:118-125, 2007。
8. Wang Y, Li Juan, Wang CY, Kwok AH, and Leung FC. Epidermal growth factor receptor (EGFR) ligands in the chicken ovary: evidence for heparin-binding EGF-like growth factor (HB-EGF) as a potential oocyte-derived signal to control granulosa cell proliferation and HB-EGF and kit ligand expression. Endocrinology 148:3426-3440, 2007。
9. Wang Y, Li Juan, Wang CY, Kwok AH, and Leung FC. Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor: evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology 148:2405-2416, 2007。
10. Wang Y, Wang Z, Li Juan, Wang Y and Leung FC. Database for chicken full-length cDNAs. Physiol Genomics 28:141-145, 2007。
11. Li Juan and Leung FC. A CR1 element is embedded in a novel tandem repeat (HinfI repeat) within the chicken genome. Genome 49:97-103, 2006。
12. Wang CY, Wang Y, Li Juan and Leung FC. Expression profiles of growth hormone-releasing hormone and growth hormone-releasing hormone receptor during chicken embryonic pituitary development. Poultry Science 85:569-576, 2006。
13. Guan Y, Peris JSM, Zheng B, Poon LLM, Chan KH, Zeng FY, Chan CWM, Chen JD, Chow KYC, Hon CC, Hui KH, Li Juan, Li VYY, Wang Y, Leung SW, Yuen KY, Leung FC. Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet 263:99-104, 2004。
14. Zeng FY, Chan CW., Chen JD, Chow KYC, Hon CC, Hui KH, Li Juan, Li VYY, Wang Y, Leung SW, Yuen KY, Leung FC. The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849. Experimental Biology and Medicine 288:866-873, 2003。
15. Wang X, Li Juan and Leung FC. Partially inverted tandem repeat isolated from pericentric region of chicken chromosome 8. Chromosome Res 10:73-82, 2002。
16. Li Juan, Wang X and Leung FC. Partially inverted repetitive satellite DNA: A potential indicator for genetic homozygosity in chicken. 7th World Congress on Genetics Applied to Livestock Production 33:113-115, 2002。

獲獎記錄


第七屆大學生《挑戰杯》課外學術活動競賽:代表香港大學獲特等獎。
2008, 2011年度四川大學青年骨幹教師獎。