殷雷

學習經歷： 2002 - 2007 博士 中國科學院生物物理研究所生物大分子國家重點實驗室 導師：王大成教授 中國科學院院士 1998 - 2002 學士 武漢大學生命科學學院 主要工作經歷與任職：中組部第六批青年項目入選者 2013 - 至今 教授武漢大學生命科學學院 2007 - 2013 研究助理 美國霍華德休斯醫學研究所（HHMI）導師：John Kappler 美國科學院院士 Philippa Marrack 美國科學院院士 英國皇家學會會系

主要研究領域和興趣：

病原識別是免疫應答中的極其重要的事件，若有效識別外源病菌或腫瘤抗原則能產生免疫保護作用，若異常識別自身或移植體抗原則又可造成機體組織的免疫損害，與感染性疾病的免疫防治、腫瘤免疫防治、自身免疫性疾病與過敏性疾病治療以及器官移植排斥等直接緊密關聯。我們從病原抗原如何被T細胞受體（TCR）識別和如何才能充分活化T細胞的角度出發，綜合了蛋白質結構測定、分子識別動力學分析、細胞水平、小鼠模型等多個層次手段進行了細緻研究。近三年已在《Immunity》、《Immunological Reviews》、《PNAS》等國際權威雜誌上以第一作者(含並列)已發表文章5篇，其中兩篇入選科學論文專業評價系統Faculty of 1000，受到科學界廣泛關注。

同時病原抗原也被天然免疫受體模式識別，與獲得性免疫識別一起對疾病的防治意義重大。我們將關注兩類免疫受體系統對病原的識別和信號傳導，多層次深入研究其機理並開發相關疾病的免疫治療方案。

參與和主持課題項目：

973課題和自然科學基金等

代表性論文：

1.Yang, J., Cheng, Z., Zhang, S., Xiong, W., Xia, H., Qiu, Y., Wang, Z., Wu, F., Qin, CF.,Yin, L., Hu, Y., Zhou, X. A cypovirus VP5 displays the RNA chaperone-like activity that destabilizes RNA helices and accelerates strand annealing.Nucleic Acids Res.2013 Dec 6 online

2.Yin,L., Jordan, K., Crawford,F., Marrack, P., Dai, S., Kappler,J. The structural based changes of the natural tumor antigen peptide vaccination breakdown the immunotolerance and evoke corssreactive T cells to protect from tumor. 2013. (In preparation)

3.Yin,L., Scott-Browne,J., Kappler,J., Huseby, E., Marrack,P., Dai, S. Cross recognition of T Cell Receptor. 2013Amino Acids(Invited Review, in preparation)( Corresponding)

4.Yin,L., Dai,S., Clayton, G.,Gao, W., Wang,Y., Kappler,J., Marrack P. Recognition of self and altered self by T cells in autoimmunity and allergy.Protein & cell2013 Jan;4(1):8-16 (Invited Review)( Corresponding)

5.Yin,L., Crawford,F., Marrack,P., Kappler,J., Dai, S. T-cell receptor(TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.PNAS（Proceedings of the National Academy of Sciences）2012 Nov 6;109(45):18517-22

Recommended by Faculty of 1000.

6.Yin,L., Scott-Browne,J., Kappler,J., Gapin, L., Marrack,P. T cells and their eons-old obsession with MHC.Immunological Reviews2012 Nov; 250(1):49-60. (Invited Review)

7.Yin,L.*, Huseby, E.*, Scott-Browne,J., Rubtsova,K., Pinilla,C., Crawford,F., Marrack, P., Dai, S., Kappler,J. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers.Immunity. 2011 Jul 22;35(1):23-33(* Contributed equally)

Comment in Immunity 35:1-3,2011. Recommended by Faculty of 1000.

8.Hu Y*, Gai Y*,Yin L*, Wang X, Feng C, Feng L, Li D, Jiang XN, Wang DC. Crystal structures of a Populus tomentosa 4-coumarate:CoA ligase shed light on its enzymatic mechanisms.Plant Cell. 2010 Sep;22(9):3093-104.(* Contributed equally)

9.Yin,L.,Xiang,Y.,Zhu,D.Y.,Yan,N.,Huang,Q.H., Wang,D.C. Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins.Proteins.2005 61：213－216

10.Yin,L.,Zhu,D.Y.,Yan,N.,Huang,Q.H., Wang,D.C. Expression, purification, and crystallization of a human protein SH3BGRL with atomic resolution.Acta Cryst. F.2005 61, 384-386

11.Zhu,Y.Q., Zhu,D.Y.,Yin,L., Zhang,Y., Vonrhein,C., Wang,D.C. Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT): The first structure of a new sequence family of transferase homologous superfamily.Proteins.2006 63:1127-1131.