賴玉平
華東師範大學
2001年獲華東師範大學生物化學與分子生物學學士學位；
2006年獲華東師範大學生物化學與分子生物學博士學位；
2005年1月到2006年6月在美國國家衛生研究所(National Institutes of Health, NIH)過敏與感染疾病研究所(National Institute of allergy and Infectious Diseases, NIAID)作聯合培養博士研究生；
2006年9月到2010年1月在美國加州大學聖地亞哥分校(University of California, San Diego)醫學院皮膚學系作博士后；
2010年1月底受聘為華東師範大學教授。
與宿主共生的一些細菌有益於宿主，這已成為近幾年的研究熱點。皮膚共生菌是如何增強皮膚免疫能力來抗衡微生物入侵和/或感染以及如何調節銀屑病人的再生胰島源蛋白3A 的表達是我們的主要研究方向。目前本課題組正與美國、韓國等國家的科學家合作，研究重點包括：1)表皮葡萄球菌的脂磷壁酸(lipoteichoic acid)對傷口炎症發生過程中Toll樣受體3(Toll-like receptor 3, TLR3)信號通路的調控機理； 2)皮膚傷口炎症發生過程中炎症因子的產生機制和腫瘤壞死因子受體相關因子1(TNF receptor-associated factor 1, TRAF1)對TLR3信號通路所引發炎症的抑制機理；3）表皮葡萄球菌誘導抗菌肽β-防禦素和鼠源再生胰島源蛋白3-γ在皮膚傷口感染中的調節機制；4）REG3A在銀屑病中的調節表達。
曾為多項美國國家衛生研究所(NIH)研究項目的主要承擔人。
Membership of Professional Societies
Society for Investigative dermatology
American Society for Microbiology
South California American Society for Microbiology Branch
1. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu Z-R, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang C-M, Ryan AF, Gallo RL. Commensal bacteria regulate TLR3-dependent inflammation after skin injury. Nat Med. Cover Story. 2009, 15(12):1377-1382.
2. Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. Feature Review. 2009, 30(3): 131-141.
3. Lai Y, Gallo RL. Toll-like receptors in skin infections and inflammatory diseases. Infect Disord Drug Targets (Formerly ''Current Drug Targets - Infectious Disorders''). 2008, 8(3): 144-155.
4. Li M, Lai Y, Villaruz AE, Cha DJ, Sturdevant DE, Otto M. Gram-positive three-component antimicrobial peptide-sensing system. Proc Natl Acad Sci U S A. 2007, 104(22):9469-9474 (Co-first author).
5. Lai Y, Villaruz AE, Li M., Cha DJ, Sturdevant DE, Otto M. The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol. 2007, 63(2):497-506.
6. Lai YP, Peng YF, Zuo Y, Li J, Huang J, Wang LF, Wu ZR. Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide. Biochem Biophys Res Commun. 2005, 328(1):243-250.
7. Lai YP, Huang J, Wang LF, Li J, Wu ZR. A new approach to random mutagenesis in vitro. Biotechnol Bioeng. 2004, 86(6): 622-627.
8. Leichtle A, Hernandez M, Ebmeyer J, Yamasaki K, Lai Y, Radek K, Choung YH, Euteneuer S, Pak K, Gallo R, Wasserman SI, Ryan AF. CC chemokine ligand 3 overcomes the bactericidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol. 2010, 184(6):3087-3097.
9. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A streptococcus. PLoS One. 2010, 5(1):e8557.
10. Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, Macleod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Dermatol. 2010, 130(1): 192-200.
11. Li M, Rigby K, Lai Y, Nair V, Peschel A, Schittek B, Otto M. Staphylococcus aureus mutant screen reveals the interaction of human antimicrobial peptide dermcidin with membrane phospholipids. Antimicrob Agents Chemother. 2009, 53(10):4200-4210.
12. Di Nardo A, Yamasaki K, Dorschner RA, Lai Y, Gallo RL. Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J Immunol. 2008, 180(11):7565-7573.
13. Li M, Cha DJ, Lai Y, Villaruz AE, Sturdevant DE, Otto M. The antimicrobial peptide-sensing system aps of Staphylococcus aureus. Mol Microbiol. 2007, 66(5): 1136-1147.
14. Yao Y, Vuong C, Kocianva S, Villaruz AE, Lai Y, Sturdevant DE, Otto, M. Characterization of the Staphylococcus epidermidis accessory gene regulator response: quorum-sensing regulation of resistance to innate host defense. J Infect Dis. 2006, 193(6):841-848.
15. Lai Y, Gallo RL. An Unique TNF alpha Inhibitor to Suppress Inflammation while Enhancing the Innate Immune System against Viral or Microbial Infections. U.S.A. patent. UCSD Ref. No. SD2008-129.
16. Gallo RL, Nizet V, Cogen A, Lai Y. Antimicrobial and anti-inflammatory therapies compositions. U.S.A. patent. UCSD Ref. No. SD2007-184.
17. Otto M, Li M, Lai Y, Villaruz AE, Cha DJ, Sturdevant DE. Gram-positive three-component antimicrobial peptide-sensing system. U.S.A. patent. Application No.60/930,709.
1. 美國Albert M. Kligman Travel Fellowship
2. 美國Outstanding graduate research at the National Institutes of Health (NIH)
3. 美國Graduate Partnerships Program Fellowship (NIAID, NIH)
4. 上海市優秀博士論文
5. 華東師範大學研究生優秀獎學金
6. 首屆中華基因網“生命之光”徵文競賽二等獎
7. 華東師範大學非師範類獎學金