古練權

畢業后留校任教，1980年赴美國State University of New York at Albany化學系學習，1981年轉入Oklahoma State University生化系任Research associate，1983年回國。1998年調入中山大學化學系，1992年任教授，1993年任博士生導師（國務院學位委員會批准）。現為中山大學藥學院藥物化學研究所所長。1986，1989，1993，1995和1998年又先後應邀赴美進行合作研究。1997年以後，多次應邀到香港科技大學、香港中文大學和香港理工大學講學和合作研究。從1983年開始，一直進行有關藥物化學、有機化學和化學生物學和的研究和教學。主持多項國家自然科學基金重點和面上項目，部省基金重大、重點和面上項目。在國內外重要刊物發表論文200多篇，專利15項(包括國內外專利)，著作4部。主持的化學專業本科《有機化學》課程於2004年被評選為國家級精品課程。現為中國化學會Chinese Chemical Letters 編委。

1.《生物有機化學》（第一作者），高等教育出版社和施普林格出版社，1998。科技圖書股份有限公司（台灣，繁體字版），2001。

2.《生物化學》（第一作者），高等教育出版社，2000。 21世紀教材系列, 獲得2002年全國普通高等學校教材二等獎）。

3. 《有機化學》（第一作者），高等教育出版社，2008。

4. 《化學生物學》（第二作者），化工出版社，2006。

（2004－2009）

1. Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-quadruplex DNA， J. Med. Chem., 2009 , 52，2825-2835.

2. 5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation, J. Med. Chem. 2008, 51, 6381- 6392.

3. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives， J. Med. Chem. 2007, 50, 1465-1474.

4. Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase， J. Med. Chem. 2005, 48, 7315.

5. Senesence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 2006, 25, 503.

6. Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells, Leukemia, 2007, 1-3.

7. G-quadruplexes: a target for anti-cancer drug design, ChemMedChem，2008, 3, 690-713 .

8. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors, Bioorg. Med. Chem., 2008, 16, 8035-8041.

9. Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives, Bioorg. Med. Chem. 2008, 16, 4617-4325.

10. 9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc, Bioorg. Med. Chem., 2008, 16, 7582-7591.

11. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA, Bioorg. Med. Chem. 2007, 15, 5493-5501.

12. Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands, Bioorg. Med. Chem. Lett, 2009, 19, 3414-3417.

13. Synthesis and antimultidrug resistance evaluation of icariin and its derivatives, Bioorg. Med. Chem. Lett, 2009, 19, 4237-4240.

14. Inhibition of thioredoxin reductase by curcumin analogs, Biosci. Biotech. Biochem., 2008, 72, 2214-2218.

15. Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors, Bioorg. Med. Chem., 2008, 16, 3790-3793.

16. A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines, Heterocycles, 2008, 75, 1773-1778.

17. Oxoisoaporphine Alkaloid Derivatives: Synthesis, DNA Binding Affinity and Cytotoxicity, Eur. J. Med. Chem., 2008, 43, 973-980.

18. Synergetic inhibition of metal ions and genistein on a-glucosidase， FEBS Letters, 2004, 576, 46-50.

19. Derivatives of oxoisoaporphine alkaloids: A novel class of selective acetycholinesterase inhibitors, Bioorg. Med. Chem. Lett. 2007, 17, 3765-3768.

20. Synergetic inhibition of genistein and a-glucose on a-glucosidase， Bioorg. Med. Chem. Lett. 2004, 14, 2947-2950.

21. Synthesis of Zwitterionic 4-Hydroxycoumarin Derivatives through a Unique Reaction of 4-Hydroxycoumarins with p- Benzoquinone and Pyridine， Org. lett., 2004, 6, 4853.

22. Novel synthesis of o-nephthothiophenequinone derivatives Regioselective via regioselective Diels-Alder reaction, Terahedron, 2005 , 61, 9097-9101.

23. An intriguing reaction of 4-hydroxycoumarins with 2,3-dichloro-5,6-dicyanobenzoquinone， Tetrahedron, 2005, 61, 3087-3090.

24. The unique regioselectivity in the formation of disubstituted-1,4-benzoquinones generated from the reaction of 4-hydroxycoumarins with 1,4-benzoquinone， Tetra. Lett. 2006, 47, 6757–6760.

25. Facile preparation of new unsymmetrical curcumin derivatives by solid-phase synthesis strategy， Tetra. Lett. 2006, 47, 4085-4089.

26. One-pot synthesis of 5,6-dihydroxylated benzo[b]furan derivatives， Tetra. Lett. 2006, 47, 2615-2618.

27. Synthesis of novel dihydrofuro [b] pyridinone derivatives : oxidation coupling of 3-hydroxy-4(1H)-pyridinone with β-dicarbonyl compounds，Tetra. Lett. 2005, 46, 5085-5088.

28. Oxoisoaporphine alkaloid derivatives:synthesis, DNA bimding affinity and cytotoxicity, Eur. J. Med. Chem，2007, 42,，in Press, corrected Proof, Available online.

29. Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin, Eur. J. Med. Chem，2007, 42, 1169-1175.

30. Synthesis, DNA binding and cytotoxity of new pyrazole emodin derivatives， Eur. J. Med. Chem. 2006, 41, 1041-1047.

31. a-Glucosidase inhibition of natural curcuminoids and curcumin analogs, Eur. J. Med. Chem. 2006, 41, 213-218.

32. Synthesis and biological evaluation of functionalized coumarins as acetycholinesterase inhibitors， Eur. J. Med. Chem. 2005, 40, 1307-1315.

33. The Molecular Mechanisms Involved in the Cytotoxicity of Alkannin Derivatives Eur. J. Med. Chem. 2005, 40, 1341-1345.

34. Synthesis and Cytotoxicity Study of Alkannin Derivatives， Eur. J. Med. Chem. 2004, 39, 755-764.

35. Apoptosis-inducing activity of new pyrazole emodin derivatives in Human Hepatocellular Carcinoma HepG2 cells, Biol. Pharm. Bull. 2007, 30, 1113-1116.

36. Synthesis and Cytotoxicity of 9-Substitued benzo[de]chromene-7,8-dione and 5-benzyl-9-Substitued benzo[de]chromene-7,8-dione， Synthesis Comm. 2006, 17, 769-772.