丁梅

1995年廈門大學學士， 2004年美國加州大學聖克魯斯分校(University of California, Santa Cruz)獲博士學位，2004至2008年美國斯坦福大學(Stanford University)博士后。2008年任中國科學院遺傳與發育生物學研究所研究員，百人計劃，博士生導師。

人類感知、學習、記憶、思維、情緒均依賴於神經系統正確的信號傳導。然而，神經系統信號傳導究竟如何發生，是什麼機制確保信息傳導的連貫性和精確性並不清楚。本實驗室立足基礎，以秀麗隱桿線蟲為模式，綜合利用分子生物學，遺傳學，活體成像，生物化學等多種研究手段，系統探索神經系統發育的分子機制。主要研究內容包括：軸突定向生長，神經細胞特異性識別，突觸形成與穩態調控。

1. Guan L#, Zhan Z#, Yang Y, Miao Y, Huang X, and Ding M*. (2020) Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons. PLoS Genetics 16(9):e1008704.

2. Ji J, Yuan J, Guo X, Ji R, Quan Q, Ding M*, Li X*, and Liu Y*. (2019) Harmine suppresses hyper-activated Ras-MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans. Cancer Cell Int doi: 10.1186/s12935-019-0880-4.

3. Guo X, Yuan J, Song X, Wang X, Sun Q, Tian J, Li X*, Ding M*, and Liu Y*. (2019) Bacteria metabolites from Peganum harmala L. polysaccharides inhibits polyQ aggregation through proteasome-mediated protein degradation in C. elegans. Int J Biol Macromol doi: 10.1016/j.ijbiomac.2020.06.091.

4. Wang J# and Ding M*. (2018) Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in C. elegans. PNAS doi:10.1073/pnas.1717468115.

5. Guan L#, Ma X#, Zhang J, Liu J, Wang Y, and Ding M*. (2016) The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLoS Genetics Jul 14;12(7):e1006163.

6. Cheng Y#, Wang J#, Wang Y, and Ding M*. (2015) Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. eLife 4:e05118.

7. Wu J#, Cheng Y, Wang J, Chen L, Ding M, and Wu J*.(2015) Structural insight into the mechanism of synergic autoinhibition of SAD kinases. Nature Communications (DOI:10.1038/ncomms9953).

8. Wang J#, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M* and Huang X*. (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development 142:1447-1457

9. Qin J#, Liang J, and Ding M*. (2014) Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons. Journal of Neuroscience 34(31):10311-10324.

10. Zhang J#, Li X, Jevince AR, Guan L, Wang J, Hall DH, Huang X*, and Ding M*. (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genetics 9(6): e1001056.

11. Song S#, Zhang B#, Sun H, Li X, Xiang Y, Liu Z, Huang X*, and Ding M*. (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics 6(8): e1003618.

12. Ding M* and Shen K. (2008) The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessay 30: 1075-1083.

13. Ding M#, King RS, Berry EC, Wang Y, Hardin J, and Chisholm AD. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PloS One 3: e3346.

14. Ding M#, Chao D, Wang G, Shen K. (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317, 947-951.

15. Ding M#, Woo WM, Chisholm AD. (2004) The cytoskeleton and epidermal morphogenesis in C. elegans. Exp Cell Res 301:84-90.

16. Ding M#, Goncharov A, Jin Y, Chisholm AD. (2003) C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development 130:5791-5801.