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張偉

暨南大學藥學院副研究員

張偉,男, 1976年出生,博士學位。2000年畢業於北京大學醫學部臨床醫學七年制,獲得本科及碩士學位。2004年至2008年就讀於香港科技大學生物化學系,獲得生物化學博士學位。畢業后在香港科技大學生物化學系從事博士后工作。2009年9月入職暨南大學,獲聘為副研究員。

科研情況


近五年代表性論文:

1.Wan J., Zhang W., Wu L., Bai T., Zhang M., Lo KW., Chui YL., Cui Y., Tao Q., Yamamoto M., Akira S. and Wu Z. BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. Mol Cell Biol. 2006; 26(2): 448-56. (共同第一作者;2009年影響因子6.057)
2. Zhang, W., Chan, H.M., Gao, Y., Poon, R. and Wu, Z. BS69 is involved in cellular senescence through the p53-p21Cip1 pathway. EMBO Reports 2007; 8: 952-8. (第一作者;2009年影響因子6.907)
3.Sun, L., Ma, K., Wang, H., Xiao, F., Gao, Y., Zhang, W., Wang, K., Gao, X., Ip, N., and Wu, Z. JAK1/STAT1/STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J. Cell Biol. 2007; 179: 129-138. (2009年影響因子9.575)
4.Yu, B., Shao, Y., Zhang, J., Dong, X. L., Liu, W. L., Yang, H., Liu, L., Li, M. H., Yue, C. F., Fang, Z. Y., Zhang, C., Hu, X. P., Chen, B. C., Wu, Q., Chen, Y. W., Zhang, W. and Wan, J. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. Br J Dermatol. 2010; 162(5):1038-43.(共同通訊作者,2009年影響因子4.26)
5.Yu B, Shao Y, Li P, Zhang J, Zhong Q, Yang H, Hu X, Chen B, Peng X, Wu Q, Chen Y, Guan M, Wan J, Zhang W. Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus. Br J Dermatol. 2010; 163(5): 935-940.(通訊作者,2009年影響因子4.26)
6.Yu, B., Shao, Y., Zhang, C., Chen, Y., Zhong, Q., Zhang, J., Yang, H., Zhang, W. and Wan, J. BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation. Exp Cell Res. 2009; 315(20): 3543-53. (共同通訊作者,2009年影響因子3.589)
7.Yu B, Wu Q, Chen Y, Li P, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Zhang W, Wan J. Polymorphisms of PXK are associated with autoantibody production, but not disease risk, of systemic lupus erythematosus in Chinese mainland population. Lupus. 2010 Sep 9.(共同通訊作者)
8.Yu B, Chen Y, Wu Q, Li P, Shao Y, Zhang J, Zhong Q, Peng X, Yang H, Hu X, Chen B, Guan M, Wan J, Zhang W. The association between single-nucleotide polymorphisms of NCF2 and systemic lupus erythematosus in Chinese mainland population. Clin Rheumatol. 2010 Sep 15.(通訊作者)
9.Li, Z., Zhang, W., Shao, Y., Zhang, C., Wu, Q., Yang, H., Wan, X., Zhang, J., Guan, M., Wan, J. and Yu, B. High-resolution melting analysis of ADAMTS18 methylation levels in gastric, colorectal and pancreatic cancers. Med Oncol. 2010; 27(3):998-1004(共同第一作者)
10.Zhang, C., Shao, Y., Zhang, W., Wu, Q., Yang, H., Zhong, Q., Zhang, J., Guan, M., Yu, B. and Wan, J. High-resolution melting analysis of ADAMTS9 methylation levels in gastric, colorectal, and pancreatic cancers. Cancer Genet Cytogenet. 2010; 196(1):38-44.
11. Zhang, W., Li, T., Shao, Y., Zhang, C., Wu, Q., Yang, H., Zhang, J., Guan, M., Yu, B. and Wan, J. Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis. J Cancer Res Clin Oncol. 2010; 136(8):1267-73.(第一作者)
12.Yu, B., Yang, H., Zhang, C., Wu, Q., Shao, Y., Zhang, J., Guan, M., Wan, J. and Zhang, W. High-resolution melting analysis of PCDH10 methylation levels in gastric, colorectal and pancreatic cancers. Neoplasma. 2010; 57(3): 247-52.(通訊作者)
13.Shao Y, Zhang W, Zhang C, Wu Q, Yang H, Zhang J, Guan M, Wan J, Yu B. High-resolution melting analysis of BLU methylation levels in gastric, colorectal, and pancreatic cancers. Cancer Invest. 2010; 28(6):642-8.(共同第一作者)
14.Yang, H., Zhang, C., Zhao, X., Wu, Q., Fu, X., Yu, B., Shao, Y., Guan, M., Zhang, W., Wan, J. and Huang, X. Analysis of copy number variations of BS69 in multiple types of hematological malignancies. Ann Hematol. 2010; 89(10): 959-64.
15.Fang Z, Xiong Y, Li J, Liu L, Li M, Zhang C, Zhang W, Wan J. Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression. Med Oncol. 2010 Jun 29.

近五年承擔的主要教學、科研項目:

1. 主持項目:JAK/STAT信號途徑在肌肉損傷修復中的作用研究,廣東省自然科學基金博士啟動項目。
2. 參與項目:一葉萩型生物鹼抑制NMDA受體活性的立體選擇性研究,國家自然科學基金青年基金項目。