臧玉峰

靜息狀態功能磁共振的計算方法學及其在神經精神疾病的應用研究

目前主要研究興趣為靜息狀態功能磁共振計算方法及其在精神疾病中的應用研究。針對靜息態腦功能磁共振信號特點，與同事提出“局部一致性”（regional homogeneity, ReHo）計算方法（Zang et al., 2004），該方法主要適用於靜息狀態功能磁共振，但也可用於任務狀態。另外，還提出了“低頻振幅”的計算方法（amplitude of low frequency fluctuation, ALFF），這兩種方法均已經被用於神經精神障礙的研究。臧玉峰課題組宋曉偉、嚴超贛等人將ReHo和ALFF方法，以及功能連接等方法集成為一個針對靜息態腦功能磁共振數據處理的免費軟體（Resting-State fMRI Data Analysis Toolkit (REST), 在應用研究方面，臧玉峰博士與國內多家醫療單位的專家展開了合作，內容涉及注意缺陷多動障礙、抑鬱症、精神分裂症、Alzheimer氏病、癲癇、帕金森氏病等。

Wang J, Wang L, Zang Y, Yang H, Tang H, Gong Q, Chen Z, Zhu C, He Y. Parcellation-dependent small-world brain functional networks: A resting-state fMRI study. Hum Brain Mapp. 2008 Jul 22. [Epub ahead of print]

Wu T, Long X, Zang Y, Wang L, Hallett M, Li K, Chan P. Regional homogeneity changes in patients with Parkinson's disease. Hum Brain Mapp. 2008 Jul 22. [Epub ahead of print]

Han Y, Yang Y, Lv YT, Zhu CZ, He Y, Tang HH, Gong QY, Luo YJ, ZANG YF, Dong Q. Gray matter density and white matter integrity in pianist’s brain: a combined structural and diffusion tensor MRI study. Neurosci Lett. 2008 (In press)

Cao Q, Zang Y, Zhu C, Cao X, Sun L, Zhou X, Wang Y. Alerting deficits in children with attention deficit/hyperactivity disorder: Event-related fMRI evidence. Brain Res. 2008 Jul 11;1219:159-68.

Zou QH, Zhu CZ, Yang Y, Zuo XN, Long XY, Cao QJ, Wang YF, Zang YF. An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: Fractional ALFF. J Neurosci Methods. 2008 Jul 15;172(1):137-41.

Long XY, Zuo XN, Kiviniemi V, Yang Y, Zou QH, Zhu CZ, Jiang TZ, Yang H, Gong QY, Wang L, Li KC, Xie S, Zang YF. Default mode network as revealed with multiple methods for resting-state functional MRI analysis. J Neurosci Methods. 2008 Jun 30;171(2):349-55.

Lv YT, Yang H, Wang DY, Li SY, Han Y, Zhu CZ, He Y, Tang HH, Gong QY, Zang YF. Correlations in spontaneous activity and gray matter density between left and right sensoritmotor areas of pianists. Neuroreport. 2008 Apr 16;19(6):631-4..

Wang L, Zhu C, He Y, Zang Y, Cao Q, Zhang H, Zhong Q, Wang Y. Altered small-world brain functional networks in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2008 Jan 24; [Epub ahead of print]

Zhu CZ, Zang YF, Cao QJ, Yan CG, He Y, Jiang TZ, Sui MQ, Wang YF. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder. Neuroimage. 2008 Mar 1;40(1):110-20.

Yuan Y, Zhang Z, Bai F, Yu H, Shi Y, Qian Y, Zang Y, Zhu C, Liu W, You J. White matter integrity of the whole brain is disrupted in first-episode remitted geriatric depression. Neuroreport. 2007 Nov 19;18(17):1845-9.

Tian L, Jiang T, Liang M, Zang Y, He Y, Sui M, Wang Y. Enhanced resting-state brain activities in ADHD patients: A fMRI study. Brain Dev. 2007 Nov 28; [Epub ahead of print]

Zuo XN, Zhu CZ, Zang YF. Mean mutual information ratio: a new method for ranking components of ICA. Progress in Natural Science 2007 17:154-160.

Wu T, Zang Y, Wang L, Long X, Li K, Chan P. Normal aging decreases regional homogeneity of the motor areas in the resting state. Neurosci Lett. 2007 Aug 23;423(3):189-193.

Wu T, Zang Y, Wang L, Long X, Hallett M, Chen Y, Li K, Chan P. Aging influence on functional connectivity of the motor network in the resting state. Neurosci Lett. 2007 Jul 18;422(3):164-8.

Chen C, Zhou X, Chen C, Dong Q, Zang Y, Qiao S, Yang T, Dong Q. The neural basis of processing anomalous information. NeuroReport. 2007 May 28;18(8):747-51.

Yang H, Long XY, Yang YH, Yan H, Zhu CZ, Zhou XP, Zang YF, Gong QY. Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI. Neuroimage. 2007 May 15;36(1):144-52.

Zhou X, Chen C, Zang Y, Dong Q, Chen C, Qiao S, Gong Q. Dissociated brain organization for single-digit addition and multiplication. Neuroimage. 2007 Apr 1;35(2):871-80.

He Y, Wang L, Zang Y, Tian L, Zhang X, Li K, Jiang T. Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study. Neuroimage. 2007 Apr 1;35(2):488-500.

Zang YF, He Y, Zhu CZ, Cao QJ, Sui MQ, Liang M, Tian LX, Jiang TZ, Wang YF. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev. 2007 Mar;29(2):83-91.

Xie S, Xiao JX, Gong GL, Zang YF, Wang YH, Wu HK, Jiang XX. Voxel-based detection of white matter abnormalities in mild Alzheimer disease. Neurology. 2006 Jun 27;66(12):1845-9.

Cao Q, Zang Y, Sun L, Sui M, Long X, Zou Q, Wang Y. Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study. Neuroreport. 2006 Jul 17;17(10):1033-6.

Tian L, Jiang T, Wang Y, Zang Y, He Y, Liang M, Sui M, Cao Q, Hu S, Peng M, Zhuo Y. Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder. Neurosci Lett. 2006 May 29;400(1-2):39-43.

Wang L, Zang Y, He Y, Liang M, Zhang X, Tian L, Wu T, Jiang T, Li K. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI. Neuroimage. 2006 Jun;31(2):496-504.

He Y, Zang Y, Jiang T, Gong G, Xie S, Xiao J. Handedness-related functional connectivity using low-frequency blood oxygenation level-dependent fluctuations. Neuroreport. 2006 Jan 23;17(1):5-8.

Gong G, Jiang T, Zhu C, Zang Y, He Y, Xie S, Xiao J. Side and handedness effects on the cingulum from diffusion tensor imaging.Neuroreport. 2005 16:1701-5.

Zang YF, Jin Z, Weng XC, Zhang L, Zeng YW, Yang L, Wang YF, Seidman LJ, Faraone SV. Functional MRI in Attention Deficit Hyperactivity Disorder: Evidence for Hypofrontality.Brain Dev. 2005 27:544-50.

Sun L, Jin Z, Zang YF, Zeng YW, Liu G, Yang L, Seidman LJ, Faraone SV, Wang YF. Differences between Attention-deficit Disorder with and without hyperactivity: A 1H-magnetic resonance spectroscopy study.Brain Dev. 2005, 27:340-4.

Lu YL, Jiang TZ, and Zang YF, Single-Trial Variable Model for Event-Related fMRI Data Analysis,IEEE Transactions on Medical Imaging. 2005, 24:236-245

Gong GL, Jiang TZ, Zhu CZ, Zang YF, Wang F, Xie S, Xiao JX and Guo XM. Asymmetry Analysis of Cingulum Based on Scale-Invariant Parameterization by Diffusion Tensor Imaging.Human Brain Mapping. 2004 28;24(2):92-98

王培織, 臧玉峰, 蔣田仔，朱朝喆，王建哲，田麗霞，梁猛，賀永. AFNI 和 SPM 腦圖像空間標準化的效果比較.中國醫學影像技術. 2004, 20:1650-1653

Zang YF, Jiang TZ, Lu YL, He Y, Tian LX, Regional Homogeneity Approach to fMRI Data Analysis.NeuroImage, 2004, 22:394-400.

Jiang TZ*, Yong He Y*, Zang YF* and Weng XC. Modulation of functional connectivity during the resting state and the motor task.Human Brain Mapping, 2004, 22:63–71.(*: Equal contribution)

Lu YL, Jiang TZ and Zang YF, Split-merge based region growing method for fMRI activation detection,Human Brain Mapping, 2004, 22(4):271-9.

Lu YL, Jiang TZ, Zang YF, Region Growing Method for the Analysis of fMRI Data.NeuroImage. 2003, 20: 455-465.

Zang YF, Jia FC, Weng XC, Li EZ, Wang YF, Hazeltine E, Ivry R. Functional organization of the primary motor cortex characterized by event-related fMRI during movement preparation and execution.Neurosci Lett 2003, 337:69–72.

Gu Y, Zang YF, Weng XC, Jia FC, Li EZ, Wang JJ. Involvement of secondary motor areas in externally-triggered single-finger movements of dominant and non-dominant hands. Chinese Science Bulletin 2003, 48:1569-1575

Lu YL, Zang YF, Jiang TZ, A Modified Temporal Self-Correlation Method for Analysis of fMRI Time Series,NeuroInformatics. 2003, 1, 259-270.

Zang YF, Gu BM, Qian QJ, Wang YF. Objective Measurement of the Balance Dysfunction in Attention Deficit Hyperactivity Disorder Children.Chinese Journal of Clinical Rehabilitation. 2002; 6(9):1372-3.

Jin Z, Zang YF, Zeng YW, Zhang L, Wang YF. Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a (1)H-magnetic resonance spectroscopy study.Neurosci Lett 2001 Nov 23; 315:45-8.

Cui SZ, Li EZ, Zang YF, Weng XC, Ivry R, Wang JJ. - Both sides of human cerebellum involved in preparation and execution of sequential movements.NeuroReport 2000; 11:3849-3853.

Zhu CZ, Zang YF, Liang M, Tian LX, He Y, Sui MQ, et al. Discriminative Analysis of Brain Function at Resting-state for Attention Deficit/Hyperactivity Disorder. In: Duncan J, Gerig G, editors. MICCAI 2005, LNCS 3750. Berlin: Springer-Verlag; 2005. p. 468-75.

He Y, Zang YF, Jiang TZ, Liang M, Gong GL. Detecting Functional Connectivity of the Cerebellum Using Low Frequency Fluctuations (LFFs). In: Barillot C, Haynor DR and Hellier P editors. MICCAI 2004, LNCS 3217. Berlin: Springer-Verlag; 2004. p. 907-15.

He Y, Zang YF, Jiang TZ, Lu YL, Weng XC, Detection of Functional Networks in the Resting Brain. 2nd IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI'04), April 15-18, 2004, Arlington, USA.