鄭毅男

先後為碩士、博士研究生主講《中藥炮製學》、《天然藥物化學》等多門課程；在科學研究上，一直從事中藥方面研究，尤其在人蔘加工理論方面頗有見地，發現紅參加工是遵循梅拉德反應的原理；同時發現人蔘中具有廣泛生理活性的AFG，是首次自人蔘中分離得到的新天然化合物，其含量超過人蔘總皂苷，為人蔘的評價和臨床應用提供了新的理論依據。曾先後主持國家、部省級科研項目15項，獲得多項科研成果，其中獲省科學技術進步二等獎1項；獲長春市科技進步二等獎1項，其中“人蔘非皂苷抗衰老保健品開發研究”經鑒定達到國際領先，已經申請“人蔘次級皂苷脂肪酸酯合成及其應用”、“人蔘果提取物的製備方法及治療糖尿病的藥物用途”等發明專利2項；多年來，發表學術論文100餘篇，其中SCI收錄9篇；出版科技著作2部。目前主要從事保健食品和癌症輔助治療藥物的研究，現正主持教育部、科技廳以及橫向聯合等3項在研基金項目。

[1]Zheng Yi-nan, Zhang Jing, Han Li-kun, Sekiya Keizo, Kimura Yoshiyuki, Okuda Hiromichi. Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism. Yakugaku Zasshi. 2005, 125(12):1005-1008.

[2]Han Li-kun, Nose Rumiko, Li Wei, Gong Xiao-jie, Zheng Yi-nan, Yoshikawa Masayuki, Koike Kazuo, Nikaido T amotsu, Okuda Hiromichi, Kimura Yoshiyuki. Reduction of fat storage in mice fed a high-fat diet long term by treatment with saponins prepared from Kochia scoparia fruit. Phytother Res, 2006, 20(10):877-882.

[3]Xiang Li, Zheng Yinan, Isabel Sattler and Wenhan Lin，Griseusin C, and novel quinone derivative from a marine-derived fungus Penicillium sp. Arch Pharm Res. 2006, 29(11): 942-945.

[4]Li Xiang, Zheng Yi-nan Lin Wen-han, Sattler Isabel. A New Vriginae Butanolide from Streptomyces sp. Chin Chem Lett, 2006, 17(11):1466-1468.

[5]Li Xiang; Li Min-yi; Zheng Yi-nan; Lin Wen-han. Structure Elucidation of Taraxerone Isolated from Mangrove Excoecaria Agallocha. Chinese Journal of Magnetic Resonance, 2006, 23(4):451-456.

[6]Li Wei, Xiang Lan, Zhang Jing, Zheng Yinan, Han Likun, Saitoc Masato. A New triterpenoid saponin from the roots of Platycodon grandiflorum. Chin Chem Lett, 2007, 18(3):306-308.

[7]Lei Jun, Li Xiang, Gong Xiao-jie, Zheng Yi-nan. Isolation, synthesis and structures of cytotoxic ginsenoside derivatives. Molecules, 2007, 12(9):2140-2150.

[8]Xu Chun-lian, Zheng Yi-nan, Yang Xiu-wei, Li Xiang-gao, Li Xiang, Chen Quan-cheng. Raddeanalin, a new flavonoid glycoside from the leaves of Salix raddeana Laksh. J Asian Nat Prod Res, 2007, 9(3-5):415-419.

[9]Li Xiang, Lei Jun, Zheng Yi-nan, Sattler Isabel, Lin Wen-han. New ent-Isopimarane Diterpene from Mangrove Excoecaria agallocha L. Chem Res Chinese U, 2007, 23(5):541-543.

[10]Han LK, Morimoto C, Zheng YN, Li Wei, Asami E, Okuda H, Saito M. Effects of Zingerone on Fat Storage in Ovariectomized Rats. YAKUGAKU ZASSHI, 2008, 128(8):1195-1201.

[11]Hu Jiang-ning, Zhu Xue-mei, Han Li-kun, Saito Masato, Sun Yin-shi, Yoshikawa Masayuki, Kimura Yoshiyuki, Zheng Yi-nan. Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae). Chem Pharm Bull, 2008, 56(1):12-16.

[12]Li Xiang, Liu Zhi, Zhang Xin-feng, Wang Li-juan, Zheng Yi-nan, Yuan Chang-chun, Sun Guang-zhi. Isolation and characterization of phenolic compounds from the leaves of Salix matsudana. Molecules, 2008, 13(8):1530-1537.

[13]Hu Jiang-ning, Zhu Xun-mei, Lee Ki-Teak, Zheng Yi-nan, Li wei, Han Li-kun, Fang Zhe-ming, Gu Li-juan, Sun Bai-sheng, Wang Chuan-yan, Sung Chang-keun. Optimization of ginsenosides hydrolyzing beta-glucosidase production from Aspergillus niger using response surface methodology. Biol Pharm Bull, 2008, 31(10):1870-1874

[14]Liu Wen-cong, Zheng Yi-nan, Masato Saito, Wang Hai-min, Yoshiyuki Kimura, Ling Ming-song, Feng Yi-xiong. Saponins from stems and leaves of Panax quinquefolium prevented high fat diet-induced obesity in mice. Phytomedicine, 2008, 15(12), 1140-11452.

[15]Cao Da-peng, Zheng Yi-nan, Qin Lu-ping, Han T, Zhang H, Rahman K, Zhang Qiao-yan. Curculigo orchioides, a traditional Chinese medicinal plant, prevents bone loss in ovariectomized rats. Maturitas, 2008, 59(4):373-380.

[16]Han Lijun, Li Wei, Han Likun, Hu Jiangning ; Wang zi ; Liu Wencong ; Zheng Yinan. Simultaneous Determination of 22 Pesticides Residues from Stem and Leaves of Panax ginseng by GC-ECD and GC-MS. Chemia Analityczna, 2009, 54(6):1433-1443.

[17]Yang Zi-juan, Liu Ce-jia, Xiang Lan, Zheng Yi-nan. Phenolic alkaloids as a new class of antioxidants in Portulaca oleracea. Phytother Res., 2009, 23(7):1032-1035

[18]Li Xiang, Liu Zhi, Chen Yun, Wang Li-juan, Zheng Yi-nan, Sun Gang-zhi, Ruan Chang-chun. Rubiacordone A: a new anthraquinone glycoside from the roots of Rubia cordifolia. Molecules, 2009, 14(1):566-572

[19]Ruan Chang-chun, Zhang Hao, Zhang Lian-xun, Liu Zhi, Sun Guang-zhi, Lei Jun, Qin Yu-xia, Zheng Yi-nan, Li Xiang, Pan Hong-yu. Biotransformation of ginsenoside Rf to Rh1 by recombinant beta-glucosidase. Molecules, 2009, 14(6):2043-2048.

[20]Li Wei, Zhang Wei, Xiang Lan, Wang Zi, Zheng Yinan, Wang Yingping, Zhang Jing, Chen Li. Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum. Molecules. 2010, 15(12):8702-8708

[21]Li Wei, Liu Zhengbo, Wang Zi, Chen Li, Sun Yinshi, Hou Jingang, Zheng Yinan. Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum. J Sep Sci. 2010, 33(12):1870-1876.

[22]Li Wei, Wang Zi, Chen Li, Zhang Jing, Han Likun, Hou Jingang, Zheng Yinan. Pressurized liquid extraction followed by LC-ESI/MS for analysis of four chromones in Radix Saposhnikoviae. J. Sep. Sci. 2010, 33(17-18):2881-2887.

[23]Hou Jingang, He Shaoyu, Ling Mingsong, Li Wei, Dong Rui, Pan Yongqi, Zheng Yinan. A method of extracting ginsenosides from Panax ginseng by pulsed electric field. J. Sep. Sci. 2010, 33(17-18):2707-2713.

[24]Han Mei, Hou Jingang, Dong Chengming, Li Wei, Yu Haolun, Zheng Yinan, Chen Li. Isolation, Synthesis and Structures of Ginsenoside Derivatives and Their Anti-Tumor Bioactivity. Molecules. 2010, 15(1):399-406.

[25]Liu Rui, Zhang Jing-zhao, Liu Wen-cong, Kimura Yoshiyuki, Zheng Yi-nan. Anti-Obesity Effects of Protopanaxdiol Types of Ginsenosides Isolated from the Leaves of American Ginseng (Panax quinquefolius L.) in Mice Fed with A High-fat Diet. Fitoterapia, 2010, 81(8):1079-1081

[26]Zhang Jing, Shi Lei-ling, Zheng Yi-nan. Dibenzocyclooctadiene lignans from Fructus Schisandrae Chinensis improve glucose uptake in vitro. Nat Prod Commun, 2010, 5(2):231-234

[27]Ruan Chang-chun, Liu Zhi, Li Xiang, Liu Xia, Wang Li-juan, Pan Hong-yu, Zheng Yi-nan, Sun Guang-zhi, Zhang Yan-sheng, Zhang Lian-xue. Isolation and Characterization of a New Ginsenoside from the Fresh Root of Panax Ginseng. Molecules 2010, 15(4), 2319-2325

[28]Li Wei, Wang Zi, Sun Yinshi, Chen Li, Han Likun, Zheng Yinan. Application of response surface methodology to optimize ultrasonic-assisted extraction of four chromones in Radix Saposhnikoviae, Phytochemical Analysis, 2011, 22(4):313-321.

[29]Li Wei, Zhang Ming, Wang Zi, Zheng Yinan, Wang Yingping, Zhang Jing. Simultaneous RP-HPLC Determination of Six Platycosides: Application to an Enzymatic Preparation Study. Chromatographia. 2011, 74(11-12):777-782

[30]Li Wei, Wang Zi, Wang Ying-ping, Jiang Chao, Liu Qun, Sun Yin-shi, Zheng Yi-nan. Pressurized liquid extraction combining LC-DAD-ESI/MS analysis as an alternative method to extract three major flavones in Citrus reticulata ‘Chachi’ (Guangchenpi), Food Chemistry. 2012, 130(4):1044-1049.