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- 中國男演員
- 中南民族大學藥學院教授
楊新洲
中南民族大學藥學院教授
男，漢族，中南民族大學藥學院教授，碩士生導師。
1995.9-1999.7：同濟醫科大學，獲理學學士學位。
2002.9-2005.7：中國科學院上海藥物研究所，獲理學博士學位（有機化學）。
2007.9-2009.1：瑞士巴塞爾大學藥學院從事博士后研究工作。
2005.7-2007.9：中國科學院上海藥物研究所，助理研究員。
2009.1-2010.12:澳大利亞格里菲斯大學Eskitis新葯發現研究所，研究員（Research Fellow）。
2010.12-至今: 中南民族大學藥學院從事教學和科研工作，副教授，教授。
中國民族醫藥學會土家醫藥學分會理事。
武漢市中藥及天然藥物專業委員會委員。
瑞士化學會會員。
澳大利亞皇家化學會會員。
Journal of Natural Products、Phytochemistry、Planta Medica、Bioorganic & Medicinal Chemistry、Bioorganic & Medicinal Chemistry Letters、Phytomedicine、Helvitica Chimica Acta、Natural Product Research等國際專業刊物的審稿人。
2、新葯中藥六類川七鎮腦寧膠囊開發研究（武漢市國家東湖高新區光谷創新人才計劃項BX219），2014-2017，100萬，項目負責人。
4、苦參抗糖尿病有效部位臨床前藥效和作用機制研究（武漢市科技計劃項目青年晨光計劃項目2013070104010028），2013-2014，10萬，項目負責人。
5、基於GLUT4靶點的苦參抗糖尿病活性物質和作用機制研究（國家自然科學基金青年項目81102798），2012-2014，22萬，項目負責人。
6、基於GLUT4靶點的苦參抗糖尿病活性物質和作用機制研究（人事部留學回國人員擇優資助項目BZY12006），2012-2014，3萬，項目負責人。
9、民族醫特色療法療效評價及平台技術研究（十二五國家科技支撐計劃項目2012BAI27B06），2011-2015，分配經費40萬，科研骨幹人員。
10、藏葯預分離組分庫建立與抗肝癌活性研究（青海省自然科學基金重點項目2012-Z-904），2012-2014，分配經費10萬，排名第二。
11、基於Caspase 3 靶點和預分離組分庫的藏葯抗肝癌藥效物質及其作用機制研究（青海省自然科學基金重點項目2016-ZJ-908），2016-2018，分配經費10萬，排名第二。
分離純化和結構鑒定來源於天然資源庫的活性天然產物，基於GLUT4和SGLT2靶點發現潛在的抗糖尿病活性化合物。
●基於天然產物庫和GLUT4及SGLT2靶點的抗糖尿病活性成分及機制研究。
● 高分辨傅里葉轉換質譜導向的小分子酶抑製劑的發現。
● 具體的研究方向。
1、基於天然產物的先導化合物發現流程。
● 中草藥及民族藥物樣品庫的建立。
● 先導化合物樣的微量提取物庫的建立。
依據新葯研發的經典規律—Lipinski五規則，我們採用特殊的柱色譜前處理技術建立了主要包含先導化合物類似組分的微量提取物庫。
● 預分離組分庫的建立。
我們開發了一種特殊的柱色譜技術用來捕捉先導化合物類似或新葯分子類似的天然產物。運用此項技術，在1000種微量提取物的基礎上，我們創建了包含多於5000個先導化合物類似或新葯分子類似的天然產物的預分離組分庫。
2、基於GLUT4靶點的抗糖尿病化合物發現。
●GLUT4是生物體調控葡萄糖吸收和利用過程的一個關鍵蛋白。
●基於GLUT4靶點的抗糖尿病活性篩選體系的建立。
●基於Ⅱ型糖尿病動物模型的體內抗糖尿病活性評價。
●基於免疫印跡技術的抗糖尿病機制研究。
1. Qi Zhou,Xinzhou Yang, Mingrui Xiong, Xiaolan Xu, Li Zhen, Weiwei Chen, Yan Wang, Jinhua Shen, Ping Zhao, Qing-Hua Liu. Chloroquine Increases Glucose Uptake via Enhancing GLUT4 Translocation and Fusion with the Plasma Membrane in L6 Cells. Cell Physiol. Biochem. 2016, 38, 2030-2040. (co-first author)。
2.Xinzhou Yang, Mi Huang, Sijian Zheng, Xinhua Ma, Dingrong Wan, Yunjiang Feng. Liquid chromatography with mass spectrometry and NMR spectroscopy based discovery of cytotoxic principles from Daphne tangutica Maxim. J. Sep. Sci., 2006, 39 (11), 2179-2187。
3. Mi Huang, Ping Zhao, Mingrui Xiong, Qi Zhou, Sijian Zheng, Xinhua Ma ,Chan Xu, Jing Yang,Xinzhou Yang, Tong-Cun Zhang. Antidiabetic activity of perylenequinonoid-rich extract fromShiraia bambusicolain KK-Ay Mice with Spontaneous Type 2 Diabetes Mellitus. J. Ethnopharmacol., 2016, 191, 71-81。
4. Karren D. Beattie, Nicola Ellwood, Rohitesh Kumar,Xinzhou Yang, Peter C. Healy, Vanida Choomuenwai, Ronald J. Quinn, Alysha G. Elliott, Johnny X. Huang, Jessica L. Chitty, James A. Fraser, Matthew A. Cooper, Rohan A. Davis. Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D–F. Phytochemistry, 2016, 124, 79-85。
5. Guangwen Shu, Lang Zhang, Shanqing Jiang, Zhuo Cheng, Guan Wang, Xu Huang,Xinzhou Yang. Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction. Oncotarget, 2016, doi: 10.18632/oncotarget.9603。
6.Mi Huang, Shihao Deng, Qianqian Han, Ping Zhao, Qi Zhou, Sijian Zheng, Xinhua Ma, Chan Xu, Jing Yang,XinzhouYang. Hypoglycemic Activity and the Potential Mechanism of the Flavonoid Rich Extract from Sophora tonkinensis Gagnep. In KK-AyMice. Frontiers in Pharmacol., 2016, doi: 10.3389/fphar.2016.00288。
7.Xinzhou Yang, Mi Huang, Jinyan Cai, Dan Lv, Jingnan Lv, Sijian Zheng, Xinhua Ma, Ping Zhao, Qiang Wang. Chemical profiling of anti-hepatocellular carcinoma constituents from Caragana tangutica Maxim. by off-line semi-preparative HPLC-NMR. Nat. Prod. Res., http://dx.doi.org/10.1080/14786419.2016.1230118。
8.Xinzhou Yang, Jing Yang, Chan Xu, Jingnan LV, Chao Wang, Ping Song. Antimicrobial stilbenoids fromBletilla yunnanensisSchltr. Chem. Nat. Comp., 2016, 52 (1), 19-22。
9. Dan Lv, Chan Xu, Mi Huang, Sijian Zheng, Xinhua Ma, Lihong Pan, Qiang Wang, Xinzhou Yang. Essential oil fromSiegesbeckia pubescensinduces apoptosis through the mitochondrial pathway in human HepG2 Cells. J. Huazhong Univ. Sci. Tech. Med. Sci., 2016, in press。
10. Chao Wang, Xinzhou Yang, GeorgeMellick, YunjiangFeng*. Meet the challenge: probing Parkinson’s disease biology by integrated multidisciplinary methodology. ACS Chemical Neuroscience, 2016, in press。
11.Xinzhou Yang,Jing Yang, Chan Xu, Mi Huang, Qi Zhou, Jingnan Lv, Xinhua Ma, Changqiang Ke, Yang Ye, Guangwen Shu, Ping Zhao. Antidiabetic effects of flavonoids fromSophora flavescensEtOAc extract in Type 2 diabetic KK-Ay mice. J. Ethnopharmacol., 2015, 171, 161-170. (co-first author)。
12. Ping Song, Qiang Wang, Jingnan Lv, Chan Xu, Qinxiong Lin, Xinhua Ma, Mi Huang,Xinzhou Yang. HPLC-based Activity profiling of Anti-Hepatocellular Carcinoma constituents from the Tibetan medicine,Caragana tibetica. J. Huazhong Univ. Sci. Tech. Med. Sci., 2015, 35 (3), 450-455。
13. Guangwen Shu, Ling Yue, Wenhao Zhao, Chan Xu, Jing Yang, Shaobing Wang,Xinzhou Yang. Isoliensinine, a bioactive alkaloid derived from embryos of Nelumbo nucifera, induces hepatocellular carcinoma cell apoptosis through suppression of NF-κB signaling. J. Agric. Food Chem., 2015, 63 (40), 8793–8803。
14. Chao Wang, Jing Yang, Ping Zhao, Qi Zhou, Zhinan Mei, Guangzhong Yang,Xinzhou Yang, Yunjiang Feng. Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities.Bioorg. Med. Chem. Lett., 2014 (14), 24, 3096-3099。
15.Xinzhou Yang, Chao Wang, Dingrong Wan, Qinxiong Lin, Guangzhong Yang, Zhinan Mei, Yunjiang Feng. Antimicrobial sesquiterpenes from the Chinese medicinal plant,Chloranthus angustifolius. Tetrahedron Letters, 2014, 55 (41), 5632-5634。
16. Guangwen Shu, Jing Yang, Chan Xu, Zhinnan Mei,Xinzhou Yang. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicology and Applied Pharmacology, 2014, 281 (2):157-65。
17. Jing Yang, Ping Zhao, Qi Zhou, Chao Wang, Dingrong Wan, Guangwen Shu, Zhinan Mei,Xinzhou Yang. Antidiabetic effect of methanolic extract fromBerberis julianaeSchneid. via activation of AMP activated protein kinase in type 2 diabetic mice. Evidence-Based Complementary and Alternative Medicine, 2014, 106206, http://dx.doi.org/10.1155/2014/106206。
18. Chao Wang, Jing Yang, Zhinan Mei,Xinzhou Yang. Acridone alkaloids with cytotoxic and antimalarial activities fromZanthoxylum simullansHance. Pharmacog. Mag., 2014, 10 (37), 73-76。
19. Jing Yang, Xinzhou Yang, Chao Wang, Qinxiong Lin, Zhinan Mei, Ping Zhao. Sodium-glucose linked transporter 2 inhibitors fromSophora flavescens. Med. Chem. Res., 2015, 24, 1265-1271。
20. Rohan Davis, Karren Beattie, Min Xu,Xinzhou Yang, Sheng Yin, Harish Hola, Peter Healy, Melissa Sykes, Todd Shelper, Vicky Avery, Mikael Elofsson, Charlotta Sundin, Ronald J Quinn. Solving the Supply of Resveratrol Tetramers from Papua New Guinean Rainforest Anisoptera Species (Dipterocarpaceae) that Inhibit Bacterial Type III Secretion Systems. J. Nat. Prod., 2014, 77 (12): 2633-2640。
21. Jingquan Yuan, Tong Li, Zhinan Mei, Jiaomei Jiang, Yaqin Zhou, Zhigang Yan, Jianhua Miao,Xinzhou Yang, Xiaojun Ma. Chemistry and Biological Activities ofHuperzia serrata. Current Opinion Complement Alternative Medicine, 2014, 1 (2), 1-11。
22.Ping Song, Jingquan Yuan,Xinzhou Yang. Cytotoxic constituents fromPsoralea corylifolia. J. Asian Nat. Prod. Res.,2013, 15 (6), 624-630。
23.Lvyi Chen , Lan Zhou, Shuwei Ma, Ling Zhao,Xinzhou Yang. Attenuation of Gouty Arthritis by Emodinol in Monosodium Urate Crystal-Treated Mice.Planta Med., 2013, 79(8), 634-638。
24.Chao Wang, Ye Yang, Zhinan Mei,Xinzhou Yang. Cytotoxic compounds fromLaminaria japonicaAresch. Chem. Nat. Comp., 2013, 49 (4), 699-701。
25.Shasha Mo, Hui Xiong,Guangwen Shu,Xinzhou Yang,Jianxia Wang,Congyi Zheng,Wei Xiong,Zhinan Mei. Phaseoloideside E, a novel natural triterpenoid saponin identified fromEntadaphaseoloides, induces apoptosis in Ec-109 esophageal cancer cells through reactive oxygen species generation. J. Pharmacol. Sci., 2013, 122 (3), 163-175。
26.Xinzhou Yang,Jinquan Yuan, Zhinan Mei,Jinfu Wan.Cytotoxic Phenolic Glycosides fromBoschniakia himalaica. Chem. Nat. Comp., 2012, 48 (4), 555-558。
27. Xinzhou Yang, Chunping Tang, Ping Zhao, Guangwen Shu, Zhinan Mei. Antimicrobial Constituents fromBletilla ochraceaSchltr. Planta Med., 2012, 78, 606-610。
28.Jinfu Wan,Jinquan Yuan, Zhinan Mei,Xinzhou Yang. Phenolic Glycosides fromBoschniakia himalaica. Chin. Chem. Lett., 2012, 23, 579-582。
29.Xinzhou Yang, Yunjiang Feng, Sandra Duffy, Vicky M Avery, David Camp, Ronald J Quinn.A new quinoline epoxide from the Australian PlantDrummondita calida. Planta Med., 2011, 77, 1644-1647。
30. Xinzhou Yang, Igor Baburin, Inken Plitzko, Steffen Hering, Matthias Hamburger. HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen (Sophora flavescensroot).Mol. Diversity,2011,15, 361-372。
31. Xinzhou Yang, Rohan A. Davis, Malcolm S. Buchanan, Sandra Duffy, Vicky M. Avery, David Camp, Ronald J. Quinn. Antimalaria bromotyrosine derivatives from the Australian marine spongeHyattellasp. J. Nat. Prod., 2010, 73, 985-987。
32.Ping Song,Xinzhou Yang, Jun Yu. New Chemical Compound fromCaragana jubata(pall.) Poir.Chem. Res. Chin. Univ., 2010, 26, 563-566。
33.Yinglu Yu, Xian Li, Changqiang Ke,Xinzhou Yang, Yang Ye. Iridoid glucosides fromAllamanda neriifolia. Chin. Chem. Lett., 2010, 21 (6), 709-711。
34. Xinzhou Yang, Peter Künze, Inken Plizolo, Olivier Potterat, Matthias Hamburger. Bicyclononane aldehydes and antiproliferative constituents fromAmomum tsao-ko. Planta Med., 2009, 75, 543-546。
35. Xinzhou Yang, Jianyu Zhu, Chunping Tang, Changqiang Ke, Ge Lin, Tin-Yan Cheng, John A. Rudd, Yang Ye.Alkaloids from roots ofStemona sessilifoliaand their antitussive activities. Planta Med., 2009, 75, 174-177。
36. 1.Li-Gen Lin,Xin-Zhou Yang, Chun-Ping Tang, Chang-Qiang Ke, Ji-Bao Zhang, Yang Ye. Antibacterial stilbenoids fromStemona tuberosa. Phytochemistry, 2008, 69, 457-463. (co-first author)。
37. Jing-Quan Yuan,Xin-Zhou Yang, Jian-Hua Miao, Chun-Ping Tang, Chang-Qiang Ke, Ji-Bao Zhang, Xiao-Jun Ma, Yang Ye.NewAntifungal triterpene glucosides from the roots ofRosa laevigataMichx.Molecules, 2008, 13, 2229-2237。
38. Xinzhou Yang, Tobias A. M. Gulder,Matthias Reichert,Chunping Tang, Changqiang Ke,Yang Ye,Gerhard Bringmann. Parvistemins A-D, a new type of dimeric phenylethyl benzoquinones fromStemona parvifloraWright. Tetrahedron, 2007, 63, 4688-4694。
39. Xin-Zhou Yang, Li-Gen Lin, Chun-Ping Tang, Yong-Qiang Liu, Yang Ye. Non-alkaloid constituents fromStemona japonica.Helv. Chim. Acta, 2007, 90, 318-325。
40. Xin-zhou Yang, Chun-ping Tang, Chang-qiang Ke and Yang Ye. Stilbenoids fromStemona sessilifolia.J. Asian Nat. Prod. Res., 2007, 9 (3), 261-266。
41. Xin-zhou Yang, Yi-ping Yang, Chun-ping Tang, Chang-qiang Ke and Yang Ye. Rapid Identification of bibenzyls ofStemona sessilifoliaby hyphenated LC-UV-NMR and LC-MS methods.Chem. J. Chin. Univ., 2007, 23, 48-51。
42. Ligen Lin, Pham-Huu Dien, ChunPing Tang, ChangQiang Ke,Xinzhou Yang, Yang Ye. Alkaloids from the roots of Stemona cochinchinensis. Helv. Chim. Acta, 2007, 90 (11), 2167-2175。
43. Fan Ge, Changqiang Ke, Wei Tang,Xinzhou Yang, Chunping Tang, Jianping Zuo, Yang Ye.Preparative isolation of some chlorogenic acids and their derivatives from Stemona japonica by high-performance liquid chromatography and evaluation of their anti-AIV (H5N1) activity in vitro.Phytochem. Anal., 2007, 18, 213-218。
44. Xin-zhou Yang, Chun-ping Tang and Yang Ye. Stilbenoids fromStemona japonica. J. Asian Nat. Prod. Res., 2006, 8 (1-2), 47-53。
1.《中國五峰特色常見藥用植物》，2014年9月，第一版，編委。
2.《湖北中藥志》，編委。
3.《中國毒性民族葯志》，2015年11月，第一版，科學出版社，第一副主編。
國家民族醫藥科學技術獎（自然科學獎）二等獎，排名第三。