陳吉龍

1992-1993年任中國科學院遺傳與發育生物學研究所（原中國科學院發育生物學研究所）助理研究員。

1993-1994年任中國科學院發育生物學研究所副研究員(中國科學院破格提拔)。

1994-1998年任美國愛荷華大學（University of Iowa）生物化學系博士后。

1998-2000年任中國科學院發育生物學研究所，副研究員、研究員、研究組負責人、青年科學家創新小組負責人。

2000-2008年任美國愛荷華大學（University of Iowa）醫學院訪問學者研究員。

2008年-至今任中國科學院“百人計劃”。中國科學院微生物研究所研究員（2017年起為兼職）、研究組負責人、博士生導師。

2013年-至今任福建農林大學動物科學學院院長，教授，博士生導師，福建省“百人計劃”入選者。

研究領域

● 在國際上最早篩選、鑒定並命名了重要的長鏈非編碼RNA--lncRNA NRAV，發現NRAV在抗病毒天然免疫反應中具有重要調控功能。

● 在國際上首次應用Knockout小鼠模型，揭示了PIM激酶家族在Abl癌基因誘發淋巴細胞癌/白血病中的關鍵性作用。

● 應用Knockout小鼠模型，揭示了Abl癌蛋白持續激活JAK/STAT信號通路的分子機理。

● 系統地研究了病原微生物入侵機體后，T細胞活化的信號轉導通路。

● 揭示了Itk/SLP76/PLC1信號通路的活化機制。

● 系統地研究了一些小分子GTPase、分子馬達蛋白在細胞內物質轉運及其與細胞轉化癌變關係的分子機理。

● 揭示了Cdc42和dynein在細胞內物質轉運中的關鍵性作用。

● 深入地研究了細胞因子信號通路的負調控機制。

● 闡明了細胞因子信號的抑制因子(SOCS1)的功能，並在國際上首次鑒定了SOCS1的磷酸化位點。

課題

正在主持及主持過國家自然科學基金重大研究計劃培育項目、重點項目、面上項目、國家“973”計劃課題、國家科技重大專項課題、國家科技支撐專項課題等20多個項目。

正在主持的項目：

（1）項目名稱：STATs蛋白在宿主抗流感病毒天然免疫中的功能研究；經費來源：國家自然科學基金聯合基金項目（促進海峽兩岸科技合作聯合基金）；

（2）項目名稱：與流感病毒致病相關的宿主長鏈非編碼RNA的篩選鑒定及功能研究；經費來源：國家自然科學基金重大研究計劃培育項目；

（3）項目名稱：流感等重要病毒與宿主動態互作的細胞分子機制；經費來源：國家重大科學研究計劃(蛋白質研究計劃)。

著作

主編專著一本（高等教育出版社，ISBN:7-04-005107-9）。

論文

1.Jiayue Hu, George Fu Gao and Ji-Long Chen*. Strengthening the role of ethnic minority women in science and medicineinChina. Lancet, 2019;393(10171):527-528. (*為通訊作者，下同)

2.Ye Chen, Jin Tian and Ji-Long Chen*. Challenges to eliminaterabies virus infection inChina by 2020. The Lancet Infectious Diseases, 2017,17(2): 135-136.

3.Fang Li, Yuhai Chen, Zhaoyuan Zhang, Jing Ouyang, Yi Wang, Ruoxiang Yan, Shile Huang, George Fu Gao, Guijie Guo and Ji-Long Chen*. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity. Nucleic Acids Research, 2015; 43(21):10321-37.

4.Jing Ouyang, Xiaomei Zhu, Yuhai Chen, Haitao Wei, Qinghuang Chen, Xiaojuan Chi, Baomin Qi, Lianfeng Zhang, Yi Zhao, George Fu Gao, Guoshun Wang and Ji-Long Chen*. NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription. Cell Host & Microbe, 2014; 16(5):616-626.

5.Haitao Wei, Song Wang, Qinghuang Chen, Yuhai Chen, Xiaojuan Chi, Lianfeng Zhang, Shile Huang, George F. Gao and Ji-Long Chen*. Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection. PLoS Pathogens, 2014; 10(1):e1003845.

6.Song Wang, Xiaojuan Chi, Haitao Wei, Yuhai Chen, Zhilong Chen, Shile Huang and Ji-Long Chen*. Influenza A virus-induced degradation of eIF4B contributes to the viral replication by suppressing IFITM3 protein expression. Journal of Virology, 2014; 88(15):8375-8385.

7.Jianling Yang, Jun Wang, Ke Chen, Guijie Guo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang and Ji-Long Chen*. eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes , 2013; 73(15): 4898-4908.

8.Song Wang, Hua Li, Yuhai Chen, Haitao Wei, George F.Gao. , Hongqiang Liu, Shile Huang and Ji-Long Chen*. Transport of influenza A virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42. , 2012, 287 (13): 9804-9816.

9.Guijie Guo, Qingzheng Kang, Xiaomei Zhu, Qinghuang Chen, Xuefei Wang, Yuhai Chen, Jing Ouyang, Lianfeng Zhang, Huo Tan, Runsheng Chen ,Shile Huang and Ji-Long Chen*. A long noncoding RNA critically regulates Bcr-Abl-mediatedcellular transformation by acting as a competitive endogenous RNA. Oncogene, 2015;34(14):1768-1779.

10.Ji-Long Chen, Andre Limnander and Paul B. Rothman. Pim-1 and Pim-2 kinases are required for Pre-B cell transformation by v-Abl oncogene. ,2008,111(3):1677-1685.

11.Guijie Guo, Xiaoxue Qiu, Song Wang, Yuhai Chen, Paul B. Rothman, Zixu Wang, Yaoxing Chen, Guoshun Wang and Ji-Long Chen*. The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B cell transformation and survival of Pim-deficient cells. , 29, 3845–3853, 2010.

12.Xuefei Wang, Shile Huang and Ji-Long Chen*. Understanding of leukemic stem cells and their clinical implications. , 2017; 16(1):2.

13.Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen*. Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway. 2019,18(1):84-95.

14.Song Wang, Lanlan Zhang, Rong Zhang, Xiaojuan Chi, Zhou Yang, Yanhui Xie, Sicheng Shu, Yuan Liao and Ji-Long Chen*. Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function. , 2018,49(1):98.

15.Yuhai Chen, Jing Ouyang,….and Ji-Long Chen*. Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23. . 2018 Nov 14;9:2641. doi: 10.3389/fimmu.2018.02641. eCollection 2018.

16.Riyue Feng, Xuefei Wang, Ke Chen, Guijie Guo, Yuan Liao, Liping Sun, Shile Huang and Ji-Long Chen*. Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis. , 2018,20(11):1095-1105.

17.Xiaoyong Chen, Shasha Liu, Mohamed Maarouf, Shile Huang and Ji-Long Chen*. Host immune response to influenza A virus infection. . 2018; 9:320.

18.Shi-long Chen, Guifeng Luo, Zhou Yang, Shuncheng Lin, Shaoying Chen, Song Wang, Mohsan Ulah Goraya, Xiaojuan Chi, Xiancheng Zeng and Ji-Long Chen*. Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways. Veterinary Research, 2016; 47(1):74.

19.Jingyun Wei, Yanmei Ma, Long Wang, Xiaojuan Chi, Ruoxiang Yan, Song Wang, Xinxin Li, Xiaoyong Chen, Wenhan Shao and Ji-Long Chen*. Alpha/beta interferon receptor deficiency in mice significantly enhances susceptibility of the animals to pseudorabies virus infection. . 2017; 203:234-244.

20.Binxiang Cai, Qingling Bai, Xiaojuan Chi, Mohsan Ullah Goraya, Long Wang, Song Wang, Biao Chen and Ji-Long Chen*. Infection with classical swine fever virus induces expression of type III interferons and activates innate immune signaling. , 2017;8:2558.

21.Song Wang, Chao Chen, Zhou Yang, Xiaojuan Chi, Jing Zhang and Ji-Long Chen*. Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome. Scientific Reports, 2016；6:23746.

22.Song Wang, Xiaoqin Luo, Ruoxiang Yan, Quanxin Wang, Qiuyue Qi, Xiaojuan Chi, Lanlan Zhang, Ziding Yu ,Binxiang Cai, Ji-Long Chen* and Hongwei Liu*. 3-anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection. Protein & cell, 2016; 7(11):839-843.

23.Zhilong Chen, Guifeng Luo, Quanxi Wang*, Song Wang*, Xiaojuan Chi, Yifan Huang, Haitao Wei, Baocheng Wu, Shile Huang and Ji-Long Chen*. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons. Veterinary Microbiology, 2015; 175(2-4):232-243.

24.Mohsan Ullah Goraya, Song Wang, Muhammad Munir and Ji-Long Chen* . Induction of innate immunity and its perturbation by influenza viruses. , 2015;6(10):712-721.

25.Qinghuang Chen, Ke Chen, GuijieGuo, Fang Li, Chao Chen, Song Wang, Grzegorz Nalepa, Shile Huang and Ji-Long Chen*. A Critical Role of CDKN3 in Bcr-Abl-Mediated Tumorigenesis. PLoS One, 2014;9(10):e111611.

26.Guijie Guo, Qingzheng Kang, Qinghuang Chen, Zhilong Chen, Jun Wang, Li Tan and Ji-Long Chen*. High expression of long noncoding RNA H19 is required for efficient tumorigenesis induced byBcr-Abloncogene. FEBS Letters, 2014; 588(9):1780-1786.

兼任中國致公黨第十五屆中央委員會委員。

兼任福建省僑聯第十屆委員會兼職副主席。

兼任福建省第十二屆政協委員。

兼任福建省科協第九屆委員會委員。

兼任中國畜牧獸醫學會獸醫公共衛生學分會副理事長。

兼任福建省畜牧獸醫學會副理事長。

兼任中國畜牧獸醫學會動物傳染病分會常務理事。

兼任福建省農業工程學會常務理事。

兼任中國微生物學會獸醫微生物專業委員會委員並任教學組副組長。

兼任《微生物學報》編委。

兼任福建省科協第九屆委員。