謝院生

留學日本5年，獲醫學博士學位。

現任解放軍總醫院（301醫院）腎臟病科主任醫師、教授，解放軍醫學院及南開大學醫學院博士生導師，全軍腎臟病研究所副所長。

主持國家重大科學研究計劃項目“哺乳動物后腎發育重要環節及關鍵調控因子的研究”

科研領域

血尿和蛋白尿的鑒別診斷、急性腎損傷的修復與再生、慢性腎臟病的腎活檢病理診斷與中西醫結合治療、腎臟發育異常及先天遺傳性腎臟疾病的診斷與腎功能保護。

課題

主持和參與國家及北京市科研項目16項；作為主要完成人之一，獲國家科技進步創新團隊獎1項，國家科技進步二等獎1項，省部級科學技術一等獎3項，中華中醫藥學會學術著作一等獎1項，中國中西醫結合學會腎臟疾病專業委員會特殊貢獻獎。

Xie Y, Nishi S, Iguchi S, Imai N, Sakatsume M, Saito A, Ikegame M, Iino N, Shimada H, Ueno M, Kawashima H, Arakawa M, and Gejyo F. Expression of osteopontin in gentamicin-induced acute tubular necrosis and its recovery process. Kidney Int. 2001; 59(3): 959-974.

Xie Y, Sakatsume M, Nishi S, Narita I, Arakawa M, and Gejyo F. Expression, roles, receptors, and regulation of osteopontin in the kidney. Kidney Int. 2001; 60(5): 1645-1657.

Sakatsume M, Xie Y, Ueno M, Obayashi H, Goto S, Narita I, Homma N, Tasaki K，Suzuki Y, and Gejyo F. Human glomerulonephritis accompanied by active cellular infiltrates shows effector T cells in urine. J Am Soc Nephrol. 2001; 12(12): 2636-2644.

Kaneko Y, Sakatsume M, Xie Y, Kuroda T, Igashima M, Narita I, Gejyo F. Macrophage metalloelastase as a major factor for glomerular injury in anti-glomerular basement membrane nephritis. J Immunol. 2003; 170(6): 3377-3385.

Xie Y, Nishi S, Ueno M, Imai N, Sakatsume M, Narita I, Suzuki Y, Akazawa K, Shimada H, Arakawa M, Gejyo F. The efficacy of tonsillectomy on long-term renal survival in patients with IgA nephropathy. Kidney Int. 2003; 63(5): 1861-1867.

Xie Y, Chen X, Nishi S, Narita I, Gejyo F. Relationship between tonsils and IgA nephropathy as well as indications of tonsillectomy. Kidney Int 2004; 65(4): 1135-1144.

Xie Y, Nishi S, Fukase S, Nakamura H, Chen X, Imai N, Sakatsume M, Saito A, Ueno M, Narita I, Yamamoto T, and Gejyo F. Different type and localization of CD44 on surface membrane of regenerative renal tubular epithelial cells in vivo. Am J Nephrol. 2004; 24(2): 188-197.

Wu J, Chen X, Xie Y, Yamanaka N, Shi S, Wu D, Liu S, and Cai G. Characteristics and risk factors of intrarenal arterial lesions in patients with IgA nephropathy. Nephrol Dial Transpl. 2005; 20(4): 719-727.

Jiang H, Zhu H, Chen X, Peng Y, Wang J, Liu F, Shi S, Fu B, Lu Y, Hong Q, Feng Z, Hou K, Sun X, Cai G, Zhang X, Xie Y. TIMP-1 Transgenic Mice Recover From Diabetes Induced by Multiple Low-Dose Streptozotocin. Diabetes. 2007; 56(1): 49-56.

Xie Y, Chen X. Epidemiology, major outcomes, risk factors, prevention and management of chronic kidney disease in China. Am J Nephrol. 2008; 28（1）：1-7.

Tu X, Chen X, Xie Y, Shi S, Wang J, Chen Y, Li J. Anti-inflammatory renoprotective effect of clopidogrel and irbesartan in chronic renal injury. J Am Soc Nephrol. 2008; 19(1): 77-83.

Zhou J, Chen X, Xie Y, Li J, Yamanaka N, Tong X. A Differential Diagnostic Model of Diabetic Nephropathy and Non-Diabetic Renal Diseases. Nephrol Dial Transplant. 2008; 23(6):1940-1945.

Liu S, Xie Y, Lv Y, Qin F, Fu B, Shi S, Yin Z, Hong Q, Zhang X, Wang J, Chang M, Chen X. A Novel Target of Mizoribine Inhibiting Mesangial Cell Proliferation: S Phase Kinase-Associated Protein 2. Am J Nephrol. 2010; 32(5): 447-455.

Liu X, Lv Y, Xie Y, Hong Q, Cai G, Zhang S, Liu W, Chen X. Change of MAX Interactor 1 Expression in an Anti-Thy1 Nephritis Model and its Effect on Mesangial Cell Proliferation. Cell Physiol Biochem. 2011; 27(3-4): 391-400.

Xie Y, Huang S, Wang L, Miao L, Zhang A, Li Y, Wu X, Wang L, Liu S, Lie C, Chen P, Chen X. The efficacy and safety of mizoribine combined with losartan in the treatment of IgA nephropathy: A multicenter, randomized, controlled study. Am J Med Sci. 2011; 341(5): 367-372.

Lu Z, Xie Y, Liu X, Cui S, Wu Y, Cai C, Zhang L, Chen X. Effect of 5/6 Nephrectomized Rat Serum on Epithelial-to-Mesenchymal Transition In Vitro. Ren Fail. 2011; 33 (6): 600-608.

Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med. 2012; 18(2): 235-243.

Lu Y, Liu X, Shi S, Su H, Bai X, Cai G, Yang F, Xie Z, Zhu Y, Zhang Y, Zhang S, Li X, Wang S, Wu D, Zhang L, Wu J, Xie Y, Chen X. Bioinformatics analysis of proteomic profiles during the process of anti-Thy1 nephritis. Mol Cell Proteomics. 2012;11(4):M111.008755-1-13.

19. Ji J, Li Q, Xie Y, Zhang X, Cui S, Shi S, Chen X. Overexpression of Robo2 causes defects in the recruitment of metanephric mesenchymal cells and ureteric bud branching morphogenesis. Biochem Biophys Res Commun. 2012; 421(3): 494-500.

Hong Q, Li C, Xie Y, Lv Y, Liu X, Shi S, Ding R, Zhang X, Zhang L, Liu S, Chen X. Kruppel-like Factor-15 Inhibits the Proliferation of Mesangial Cells. Cell Physiol Biochem. 2012;29(5-6):893-904.

Hu J, Zhang L, Wang N, Ding R, Cui S, Zhu F, Xie Y, Sun X, Wu D, Hong Q, Li Q, Shi S, Liu X, Chen X. Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions. Kidney Int. 2013;84(3):521-531.

Lu ZY, Liu SW, Xie YS, Cui SY, Liu XS, Geng WJ, Hu X, Ji JY, and Chen XM. Inhibition of the Tubular Epithelial-to-Mesenchymal Transition in vivo and in vitro by the Uremic Clearance Granule. Chin J Integr Med. 2013;19(12): 918-926.

Jin M, Zhu S, Hu P, Liu D, Li Q, Li Z, Zhang X, Xie Y, Chen X. Genomic and epigenomic analyses of monozygotic twins discordant for congenital renal agenesis. Am J Kidney Dis. 2014;64(1):119-122.

Wang X, Tao T, Ding R, Song D, Liu M, Xie Y, Liu X. Kidney Protection against Ischemia/Reperfusion Injury by Myofibrillogenesis Regulator-1. Am J Nephrol. 2014;39(4):279-287.

Jin M, Hu P, Ding R, Chen P, Qiu Q, Wu J, Liu S, Xie Y, Chen X. Effectiveness of supine/standing urinalysis for differential diagnosis of left renal vein entrapment syndrome combined with or without glomerulopathy. Nephrology (Carlton). 2014;19(6):332-338

Jin M, Xie Y, Li Q, Chen X. Stem Cell-Based Cell Therapy for Glomerulonephritis. Biomed Res Int. 2014;2014:124730.

Hu P, Jin M, Xie Y, Chen P, Zhang X, Yin Z, Cai G, Chen X. Immunoglobulin A nephropathy in horseshoe kidney: case reports and literature review. Nephrology (Carlton). 2014;19(10):605-609.

Yang Y, Xie Y, Wang C, Chen G, Kong D, Zhou Z, Wang Y, Qi K, Song M, Ma L. Establishing Equations to Evaluate 24-Hour Urine Protein Excretion Using Routine Urinalysis. Nephrology (Carlton). 2014;19(11):685-692.

謝院生, 陳香美. 扁桃體與IgA腎病的發病和治療. 中華腎臟病雜誌

謝院生, 陳香美. 急性腎小管壞死后的修復與再生. 中華腎臟病雜誌

謝院生. 咪唑立賓在腎臟病中的應用. 中國中西醫結合腎病雜誌

謝院生. 地震擠壓傷導致急性腎衰竭的救治. 武警醫學

謝院生，陳香美. 加深對橫紋肌溶解症的認識. 軍醫進修學院學報

謝院生，劉曉巒，陳香美. 運動性橫紋肌溶解症的診治. 軍醫進修學院學報

謝院生，劉曉巒，陳香美. 橫紋肌溶解致急性腎損傷的診治. 中國血液凈化

謝院生，周建輝，陳香美. 糖尿病腎病早期診斷與防治. 北京醫學

謝院生，陳香美. IgA腎病病情評估及預后判斷的無創生物標誌物. 中國中西醫結合腎病雜誌

謝院生，劉曉巒，陳香美. 胚腎發育相關的生長因子在急性腎損傷修復再生中的作用. 武警醫學

謝院生, 劉玉寧. 糖尿病腎病的診斷與中西醫結合治療[J/CD]. 中華腎病研究電子雜誌.

謝院生，齊焰，章友康. 慢性腎臟病的脂質管理及非他汀類調脂葯的臨床應用. 中國醫院用藥評價與分析

（1）國家科技進步創新團隊獎（相當於國家科技進步一等獎）1項；

（2）國家科技進步二等獎1項；

（3）省部級科學技術一等獎3項；

（4）中華中醫藥學會學術著作一等獎1項；

（5）中國中西醫結合學會腎臟疾病專業委員會特殊貢獻獎。

中國中西醫結合學會腎臟疾病專業委員會常委兼秘書長

北京中西醫結合學會常務理事兼學術工作委員會副主任委員

北京中西醫結合學會腎臟病專業委員會副主任委員

《中國中西醫結合腎病雜誌》副總編輯

《中華腎病研究電子雜誌》（中華醫學會系列雜誌）編輯部主任

國家重大科學研究計劃項目首席科學家

中國中西醫結合學會腎臟疾病專業委員會秘書長