粒細胞-巨噬細胞集落刺激因子

拉丁名

Granulocyte-macrophage Colony Stimulating Factor (GM—CSF）

別名

重組人粒細胞巨噬細胞集落刺激因子、生百能、沙格莫丁。

作用和用途

本品能興奮骨髓的造血功能、刺激粒細胞、單核細胞、T細胞的增殖，並能促進單核細胞和粒細胞的成熟。本品能克服放療和化療引起的骨髓毒性，縮短腫瘤化療時中性粒細胞減少的時間，使患者易於耐受化療。由於本品能增強單核細胞、粒細胞、嗜酸性細胞和巨細胞的功能能，能提高機體抗腫瘤及抗感染免疫力。

用法

靜滴或皮下注射，用量須遵醫囑。

副作用及注意事項

對本品過敏或自身免疫性血小板減少性紫癜者忌用。孕婦、哺乳期婦女、未成年人及惡性骨髓腫瘤病人慎用。此外，還有發熱、骨痛、肌痛、腎功能減退，靜脈炎、腹瀉、乏力、短暫心律失常等不良反應。

[英漢醫學詞典]GM-CSF

[=granulocyte-macrophage colony stimulating factor]粒細胞-巨噬細胞集落刺激因子

[=granulocyte-macrophage colony stimuluting factor]顆粒球巨噬細胞株刺激因子，粒細胞巨噬細胞集落刺激因子

[=granular cell macrophages-colony stimulating factor]粒細胞巨噬細胞-集落刺激因子

[英文MESH詞典]GM-CSF

〖同義詞〗GM-CSF

〖主題詞〗Granulocyte-Macrophage Colony-Stimulating Factor

〖英文釋義〗An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes,macrophages,and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.

[英漢總索引詞典]GM-CSF

[英漢藥名關聯詞典]gm-csf

〖中文通用名〗沙格司亭

〖英文通用名〗sargramostim

〖所屬類別〗影響機體免疫功能的藥物/其它類