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王平

同濟大學醫學院副院長

王平,男,博士,現任同濟大學醫學院副院長、教授、博士生導師。

個人履歷


1.2017.03-至今:同濟大學醫學院副院長;
2.2015.02-至今:同濟大學生命科學與技術學院/同濟大學醫學院教授及博士生導師;
3.2015.02-2017.03:上海市第十人民醫院科研處處長、上海市第十人民醫院中心實驗室主任;
4.2008.07-2015.02:華東師範大學生科院生命醫學研究所教授及博士生導師、生命醫學系系主任,生化與分子生物學學科主任、上海市調控生物學重點實驗室PI;
5.2006.10-2008.06:美國耶魯大學藥理學系博士后;
6.2006.01-2006.10:美國康涅狄格大學健康中心博士后;
7.2003.01-2005.12:美國明尼蘇達大學藥理學系博士后;
8.1997.09-2002.07:中科院上海生化與細胞生物研究所博士;
9.1992.09-1997.07:復旦大學生命科學學院學士。

社會兼職


1.國家自然科學基金函評專家、生命學部專家評審組成員;
2.中國細胞生物學學會,常務理事;
3.上海市生物化學與分子生物學學會,常務理事;
4.中國病理生理學會第一屆蛋白質修飾與疾病專業委員會,委員;
5.中國抗癌協會第一屆微環境專業委員會,副主任委員;
6.中國醫藥生物技術轉化醫學分會第二屆委員會,常務委員;
7.中國細胞生物學學會腫瘤細胞生物學分會,秘書長;
8.上海市細胞生物學學會,副理事長;
9.上海市免疫學會腫瘤免疫專業委員會,委員;
10.Editorial Board Member:World Journal of Biological Chemistry。

研究方向


1.全基因組鑒定腫瘤免疫微環境(TIME)調控基礎研究;
2.蛋白質翻譯后修飾調控腫瘤營養代謝機制研究;
3.腫瘤宏環境與腫瘤微環境相互作用機制;
4.靶向腫瘤微環境在腫瘤診療中的轉化研究。

代表論著


(1)Xinbo Wang(#), Yueqing Chen(#), Xudong Wang(#), Hongling Tian, Yanjin Wang, Jiali Jin, Zezhi Shan, Yu e Liu, Zhenyu Cai, Xinyuan Tong, Yi Luan, Xiao Tan, Bing Luan, Xin Ge, Hongbin Ji, Xuejun Jiang, Ping Wang(*). Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11. Cancer Research, 2021.8.21 online.
(2)Wen Zhang(#), Jiali Jin(#), Yanjin Wang(#), Lan Fang, Liu Min, Xinbo Wang, Lin Ding, Linjun Weng, Tan Xiao, Tianhua Zhou & Ping Wang(*). PD-L1 regulates genomic stability via interaction with Cohesin-SA1 in the Nucleus. Signal Transduction and Targeted Therapy, 2021.2.25,6:81.
(3)Jiawen Zhang (#), Yunfei Chen (#), Xianfei Chen, Wen Zhang , Linlin Zhao, Linjun Weng, Hongling Tian, Zhiqiang Wu, Xiao Tan, Xin Ge, Ping Wang(*), Lan Fang(*). Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer. Cell Death & Differentiation, 2021 Jan;28(1):139-155.
(4)Zhiqiang Wu(#), Linjun Weng(#), Tengbo Zhang(#), Hongling Tian, Lan Fang, Hongqi Teng, Wen Zhang, Jing Gao, Yun Hao, Yaxu Li, Hu Zhou & Ping Wang(*). Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis. Cell Research, 2019.2; 29(2):136-150.
(5)Deng Lu(#); Chen Lei(#); Zhao Linlin; Xu Yan; Peng Xiaoping; Wang Xinbo; Ding Lin; Jin Jiali; Teng Hongqi; Wang Yanming; Pan Weijuan; Yu Fei; Liao Lujian; Li Li; Ge Xin; Wang Ping(*). Ubiquitination of Rheb governs growth factor-induced mTORC1 activation. Cell Research, 2019.2,29(2):136-150.
(6)Xinbo Wang(#); Jiali Jin(#); Fangning Wan(#); Linlin Zhao(#); Hongshang Chu; Cong Chen; Guanghong Liao; Jian Liu; Yue Yu; Hongqi Teng; Lan Fang; Cong Jiang; Weijuan Pan; Xin Xie; Jia Li; Xiaolin Lu; Xuejun Jiang; Xin Ge(*); Dingwei Ye(*); Ping Wang(*), AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness. Developmental Cell, 2019.1, (48): 1~16.
(7)Fang Lan(#); Teng Hongqi(#); Wang Yilin(#); Liao Guanghong(#); Weng Linjun; Li Yaxu; Wang Xinbo; Jin Jiali; Jiao Chenchen; Chen Lei; Peng Xiaoping; Chen Jiayu; Yang Yongzhi; Fang Houqin; Han Dongyan; Li Cheng; Jin Xueling; Zhang Shihao; Liu Zhongchen; Liu Min; Wei Qing; Liao Lujian; Ge Xin; Zhao Bin; Zhou Dawang; Qin Huan-Long; Zhou Jun; Wang Ping(*). SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis. Cancer Cell, 2018.7.9, 34(1): 103.
(8)Zhao, Linlin(#); Wang, Xinbo(#); Yu, Yue; Deng, Lu; Chen, Lei; Peng, Xiaoping; Jiao, Chenchen; Gao, Guoli; Tan, Xiao; Pan, Weijuan; Ge, Xin(*); Wang, Ping(*), OTUB1 suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR. Journal of Biological Chemistry, 2018.3.30, 293(13): 4883~1892.
(9)Chen, Yunfei(#),Wang, Lufan(#),Jin, Jiali,Luan, Yi,Chen, Cong,Li, Yu,Chu, Hongshang,Wang, Xinbo,Liao, Guanghong,Yu, Yue,Teng, Hongqi,Wang, Yanming,Pan, Weijuan,Fang, Lan,Liao, Lujian,Jiang, Zhengfan,Ge, Xin,Li, Bin,Wang, Ping(*). p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation. Journal of Experimental Medicine,2017.4,214(4):991~1010.
(10)Liao, Peng(#); Wang, Weichao(#); Li, Yu(#); Wang, Rui(#); Jin, Jiali(#); Pan, Weijuan; Chen, Yunfei; Shen, Mingyue; Wang, Xinbo; Jiang, Dongyang; Pang, Jinjiang; Liu, Mingyao; Lin, Xia; Feng, Xin-Hua; Wang, Ping(*); Ge, Xin(*), Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis. eLife, 2017.3.31, 6.
(11)Jin, Jiali(#); Liu, Jian(#); Chen, Cong; Liu, Zhenping; Jiang, Cong; Chu, Hongshang; Pan, Weijuan; Wang, Xinbo; Zhang, Lingqiang; Li, Bin; Jiang, Cizhong; Ge, Xin; Xie, Xin(*); Wang, Ping(*), The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nature Communications, 2016.11.25, 7.
(12)Jinxia Sun(#),Yi Luan(#),Dong Xiang,Xiao Tan,Hui Chen,Qi Deng,Jiaojiao Zhang,Minghui Chen,Hongjun Huang,Weichao Wang,Tingting Niu,Wenjie Li,Hu Peng,Shuangxi Li,Lei Li,Wenwen Tang,Xiaotao Li(*),Dianqing Wu(*),Ping Wang(*), The 11S proteasome subunit PSME3 is a positive feedforward regulator of NF-κB and important for host defense against bacterial pathogens. Cell Reports,2016.2.2,14(4):737~749.
(13)Wang, W.(#),Liao, P.(#),Shen, M.,Chen, T.,Chen, Y.,Li, Y.,Lin, X.,Ge, X.(*),Wang, P.(*), SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62. ONCOGENE,2016.1.28,35(4):491~500.
(14)Jinjin Pan(#),Qi Deng,Cong Jiang,Xinbo Wang,Tingting Niu,Hui Li,Taiqi Chen,Jiali Jin,Weijuan Pan,Xiaopan Cai,Jianru Xiao(*),Ping Wang(*), USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer. Oncogene,2015.7,34(30):3957~3967.
(15)Li, S.(#); Jiang, C.(#); Pan, J.; Wang, X.; Jin, J.; Zhao, L.; Pan, W.; Liao, G.; Cai, X.; Li, X.; Xiao, J.(*); Jiang, J.(*); Wang, P.(*), Regulation of c-Myc protein stability by proteasome activator REG gamma. Cell Death and Differentiation, 2015.6, 22(6): 1000~1011.
(16)Lu Deng(#),Cong Jiang(#),Lei Chen(#),Jiali Jin,Jie Wei,Linlin Zhao,Minghui Chen,Weijuan Pan,Yan Xu,Hongshang Chu,Xinbo Wang,Xin Ge,Dali Li,Lujiang Liao,Mingyao Liu,Li Li,Ping Wang(*) , The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation. Molecular Cell,2015.6.4,58(5):804~818.
(17)Chen, Yunfei(#),Wang, Lufan(#),Cheng, Xiaomu,Ge, Xin,Wang, Ping(*), An ultrasensitive system for measuring the USPs and OTULIN activity using Nanoluc as a reporter. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014.12.12, 455(3-4):178~183.
(18)Peng Liao(#),Weichao Wang(#),Mingyue Shen,Weijuan Pan,Kai Zhang,Rui Wang,Taiqi Chen,Yihua Chen,Huaqing Chen,Ping Wang(*), A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis. Cell Death and Disease, 2014.1, 5.
(19)Rong Li(#),Jie Wei(#),Cong Jiang(#),Dongmei Liu,Lu Deng,Kai Zhang,Ping Wang(*), Akt SUMOylation Regulates Cell Proliferation and Tomorigenesis. Cancer Research,2013.9.15,73(18):5742~5753 .
(20)Rui Wang(#),Yan Wang(#),Ning Liu(#),Chunguang Ren(#),Cong Jiang,Kai Zhang,Su Yu,Yunfei Chen,Hui Tang,Qi Deng,Fu Cong,Yingcong Wang,Rong Li,Mingyao Liu,Weijun Pan,Ping Wang(*), FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Research,2013.6,23(6):803~819.
(21)Ning Xiao(#),Hui Li(#),Jian Luo(#),Rui Wang,Haiquan Chen,Jiquan Chen(*),Ping Wang(*), Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNF alpha-induced cancer cell migration. Biochemical Journal,2012.2.1,441(3):979~98.
(22)Wenwen Xu(#),Ping Wang(#)(*),Bjoern Petri,Yong Zhang,Wenwen Tang,Le Sun,Holger Kress,Tom Mann,Yan Shi,Paul Kubes,Dianqing Wu(*), Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality and In Vivo Infiltration. Immunity,2010.9.24,33(3):340~350.
(23)Ning Liu(#),Hui Li,Shuangxi Li,Mingyue Shen,Ning Xiao,Yunfei Chen,Yan Wang,Weichao Wang,Rui Wang,Qian Wang,Jianhua Sun,Ping Wang(*), The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs. Journal of Biological Chemistry,2010.6.11,285(24):18858~18867.

主要成就


1.2019年:長江學者獎勵計劃特聘教授;
2.2019年:第四批國家“萬人計劃”;
3.2018年:科技部創新人才推進計劃中青年科技創新領軍人才;
4.2018年:上海領軍人才;
5.2017年:上海衛生系統優秀學科帶頭人;
6.2016年:國家基金委傑出青年基金獲得者;
7.2013年:上海市‘青年科技啟明星’追蹤人才計劃;
8.2012年:國家基金委優秀青年基金獲得者;
9.2011年:上海市‘曙光學者’人才計劃;
10.2010年:教育部‘新世紀人才’計劃;
11.2009年:上海市‘青年科技啟明星’人才計劃;
12.2006年:AHA Postdoctoral fellowship;
13.2000年:中科院地奧獎學金;
14.1999年:中科院偉華獎學金。