屠鵬飛

1988年至1989年在日本富山醫科藥科大學和漢葯研究所學習。

1990年9月進入北京醫科大學藥學院進行博士后研究。

1992年12月博士后出站后留校工作至今。

1993年被聘為副教授，1997年被聘為教授，1999年被評為博士生導師。

現任北京大學藥學院天然藥物化學系主任，教授，博士生導師。

中藥活性成分與新葯研究

天然活性成分結構改造與構效關係研究

中藥質量分析

中藥活性成分的體內藥物學研究

研究成果

對肉蓯蓉屬、遠志屬、鐵線蓮屬、大風子科藥用植物及中藥黃芪、紅花等40多種中藥和天然藥物及中藥復方“補陽還五湯”等進行了系統的活性成分研究，分離鑒定了1600多個化合物，其中新化合物400多個；發現肉蓯蓉中所含的部分苯乙醇苷類成分具有明顯的抑制神經細胞凋亡、促進神經細胞生長作用，闡明其作用機理，並將其研製成為治療老年痴呆症的二類新葯；遠志皂苷具有明顯的抑制基因轉染的神經細胞Aβ的分泌，並闡明其作用機理；廣西血竭中所含的黃酮類成分具有明顯的抑制血小板聚集、抗血栓等作用，部分黃烷類成分具有明顯的抗真菌作用。對大黃、黃芪、紅花等20多種中藥及黃芪注射液等5種中藥注射劑進行了系統的質量標準包括指紋圖譜檢測標準的研究，建立了有效的質量控制方法。已研製一類新葯1項，五類新葯10多項，在研新葯多項。研究成果獲得國家科技進步獎一等獎、三等獎各1項、教育部自然科學獎一等獎和科技進步獎一等獎各1項、國家中醫藥管理局科技進步獎一等獎2項、中華中醫藥學會李時珍醫藥創新獎1項、湖北省科技進步獎三等獎1項、新疆和田地區科技特等獎1項，並獲得2001年度中國藥學發展獎－地奧藥學科學技術獎（中藥獎）三等獎、2002年度茅以升科技教育獎－北京青年科技獎等榮譽獎。發表科研論文300餘篇，其中SCI收載100多篇，著作9部，申請和授權專利30多項。

科研論文

1. Cunqin Jia, Haiming Shi, Wei Jin, Ke Zhang, Yong Jiang, Mingbo Zhao, andPengfei Tu*.Metabolism of Echinacoside, a Good Antioxidant, in Rats: Isolation and Identification of Its Biliary Metabolites.Drug Metabolism and Disposition, 2009, 37:431–438

2.Zheng-Ren Xu, Xing-Yun Chai, Chang-Cai Bai, Hong-Yan Ren, Ya-Nan Lu, Hai-Ming Shi,Peng-Fei Tu*. Xylocosides A-G, phenolic Glucosides from the Stems ofXylosma controversum,Helvetica Chimica Acta, 2008(91): 1346-1354

3.Xing Yun Chai, Yue Lin Song, Zheng Ren Xu, Hai Ming Shi, Chang Cai Bai, Dan Bi, Jing Wen, Fei Fei Li, andPeng Fei Tu*.Itosides J-N from Itoa orientalis and structure - Anti-COX-2 activity relationship of phenolic glycosides,Journal of Natural Products,2008(5) : 814-819

4.Xing-Yun Chai, Chang-Cai Bai, Hai-Ming Shi, Zheng-Ren Xu, Hong-Yan Ren, Fei-Fei Li,Ya-Nan Lu, Yue-Lin Song,Peng-Fei Tu* . Six insecticidal isoryanodane diterpenoids from the bark and twigs of Itoa Orientalis ,Tetrahedron, 2008 (64): 5743–5747

5.Lei Liu, An-Liang Li, Ming-Bo Zhao, Peng-Fei Tu. Tetralones and Flavonoids fromPyrola calliantha.Chemistry & Biodiversity. 2007, 4:2932-2937

6.Wei Jin, Ying-Feng Wang, Ri-Li Ge, Hai-Ming Shi, Cun-Qin Jia andPeng-Fei Tu*. Simultaneous analysis of multiple bioactive contituentes inRheum tanguticumMaxim. Ex Balf. By high-performance liquid chromatography coupled to tandem mass spectrometry.Rapid Communications in Mass Spectrometry,2007, 21:2351-2360

7.Guang-bo Xie, Lian-di Lei,Peng-fei Tu*.Complete assignments ofH andC NMR spectroscopic data for two new triterpenoid saponins fromIlex pernyi,Magnetic Resonance in Chemistry, 2007, 45:997-1000

8.Shepo Shi, Dan Jiang, Mingbo Zhao,Pengfei Tu*. Preparative isolation and purification of triterpene saponins fromClematis mandshuricaby high-speed counter-current chromatography coupled with evaporative light scattering detection,Journal of Chromatography B. 2007, 852:679-683

9.Y. Jiang , P. Li , S. P. Li , Y.T.Wang ,P. F. Tu*. Optimization of pressurized liquid extraction of five major flavanoids fromLysimachina clethroide.Journal of Pharmaceutical and Biomedical Analysis, 2007, 43:341-345

10.Cunqin Jia, Haiming Shi, Xiangmei Wu, Yinzeng Li, Jingjing Chen,Pengfei Tu*. Determination of echinacoside in rat serum by reversed-phase high-performance liquid chromatography with ultraviolet detection and its application to pharmacokinetics and bioavailability.Journal of Chromatography B. 2006, 844: 308-313

11.Jiang D, Gao QP, Shi SP, Tu PF*.Triterpenoid saponins from the fruits of Akebiae quinata.Chemical & Pharmaceutical Bulletin. 2006, 54 (5): 595-597

12.Wu XM, Dai H, Huang LX,Tu Pengfei*.A fructan, from radix ophiopogonis, stimulates the proliferation of cultured lymphocytes: Structural and functional analyses.Journal of Natural Products. 2006, 69 (9): 1257-1260

13.Shi SP, Jiang D, Dong CX,Pengfei Tu*.Triterpene Saponins fromClematis mandshurica.Journal of Natural Products. 2006, 69 (11): 1591-1595

14.Hai-Ming Shi, Jing Wen, Cun-Qin Jia, Wei Jin, Xiu-Feng Zhang, Zhi-Rong Yao,Peng-Fei Tu*. Two new phenolic glycosides from the barks of Hydnocarpus annamensis and their Anti-inflammatory and Anti-Oxidation Activities,Planta Medica, 2006, 72 (10) :948-950

15.Wei Jin, Ri-Li Ge, Quan-Jia Wei, Tian-You Bao, Hai-Ming Shi,Peng-Fei Tu*. Developmeng of high-performance liquid chromatographic fingerprint for the quality control ofRheum tanguticumMaxin. ex Balf.Journal of chromatography A, 2006, 1132:320-324

16.Pengfei Tu*, Zhihong Song, Haiming Shi, Yong Jiang, Yuying Zhao. Arylethyl ( =Phenylethanoid ) Glycosides and Oligosaccharide from the Stem of Cistanche tubulosa ,Helvetica Chimica Acta, 2006, 89 : 927～935

17.Y. Jiang, S. P. Li, H. T. Chang, Y. T. Wang,P. F. Tu*, Pressurized liquid extraction followed by high-performance liquid chromatography for determination of seven active compounds in Cortex Dictamni,Journal of Chromatography A, 2006 , 1108: 268-272

18.Xiang Mei Wu, Xiao Ming Gao, Karl W.K. Tsim andPeng Fei Tu*, An arabinogalactan isolated from the stems of Cistanche deserticola induces the proliferation of cultured lymphocytes ,International Journal of Biological Macromolecules, 2005, 37:278-282

19.Jun Li , Yong Jiang, andPengfei Tu*, Xanthone O-Glycosides and Benzophenone O-Glycosides from the Roots of polygala tricornis,Journal of Natural Products,2005, 68:1802-1804

20.Yong Jiang, Wei Zhang , Pengfei Tu*, Xiaojie Xu. Xanthone Glycosides fromPolygala tenuifoliaand Their Conformational Analyses ,Journal of Natural Products, 2005, 68: 875-879

任第九屆國家藥典委員會中藥材飲片專業委員會主任委員，國家食品藥品監督管理局藥品審評委員，中國高科技產業化研究會理事，中國中醫藥研究促進會藥品管理與中藥知識產權專業委員會副主任委員，中國藥學會中藥與天然藥物專業委員會委員，北京市生物技術和新醫藥產業促進中心核心專家，國家標準樣品技術委員會天然產物標準樣品專業工作組專家，《中國藥學》（英文版）《中藥新葯與臨床藥理》雜誌副主編，《藥學學報》《中草藥》《中國中藥雜誌》《中國天然藥物》《中國藥科大學學報》《實驗方劑學》《中國現代中藥》《醫藥經濟報》《中國醫藥工業雜誌》《中國藥學雜誌》等編委，中國藥科大學、瀋陽藥科大學、北京中醫藥大學、黑龍江中醫藥大學、三峽大學、大連理工大學、內蒙古醫學院、西北大學、中國醫學科學院藥用植物研究所等客座教授。