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張弓
暨南大學生命科學技術學院研究員
張弓，男，1981年生。現任暨南大學生命科學技術學院研究員，暨南大學翻譯組學實驗室負責人，博士生導師。國家優秀青年基金獲得者，國家863青年科學家，國家萬人計劃“青年拔尖人才”。廣東省科技特派員，國際人類蛋白質組計劃中國團隊骨幹研究成員，中國生化與分子生物學學會蛋白質組學專業委員會(CNHUPO)理事，中國分子系統生物學專業委員會委員。獲美國化學學會頒發的會員獎。
張弓教授，2001年獲武漢大學生物學學士學位，2005年獲漢堡科技大學生物技術碩士學位，2009年6月獲博士學位。世人皆知在德國攻讀博士學位少有人能按時畢業，而張弓不僅三年攻下博士學位，其博士階段科研成果挑戰1972年諾貝爾化學獎結論，博士論文與答辯更是獲得德國最高成績（summa cum laude，最高榮譽），2010年獲德國Michelson-Preis最佳博士生大獎，成為第一位獲此榮譽的華人。
張弓教授研發FANSe系列超高精度大規模測序序列比對演演算法，是目前精度最高的演演算法，有效解決大規模測序的可驗證性、可重複性問題，並於2018年創造了單機“一小時全基因組、一分鐘全外顯子組、一秒鐘全轉錄組”分析的世界紀錄。作為創始人之一創立深圳承啟生物科技有限公司，基於FANSe系列演演算法建立了世界上第一個高度實用化的基因測序分析雲平台，進而打破美國的壟斷，建立了第一個全國產化的測序分析全流程，使中國精準醫學不再受制於人。在多個緊急臨床案例中起到了關鍵作用，為大眾提供低成本、高精度的健康及臨床測序信息服務，被邀請作TED演講。參與中國緬甸遠征軍遺骸DNA鑒定工作，測定了遠征軍遺骸的全基因組序列，這是世界上首次成功對超過70年熱帶地區遺骸進行DNA鑒定，被鳳凰衛視、湖南衛視、廣東電視台、廣州日報等媒體廣泛專訪報道。
發現翻譯速率調控是決定蛋白質摺疊的關鍵因素之一，對1972年諾貝爾化學獎理論“安芬森原則”作出顛覆性更新。首次實現高等生物翻譯中mRNA全長測序，揭示了翻譯調控在生物信息傳遞中的關鍵地位，建立了翻譯中mRNA與蛋白質丰度之間的定量關係，將中心法則定量化。由此建立翻譯組學新學科領域，率先開發出翻譯過程中幾乎所有部分的組學測定方法。翻譯組分析被作為國際人類蛋白質組計劃(HPP)的核心支柱之一。2016年翻譯組學被寫進國家統編教材，成為生化與分子生物學方向上第一個被寫進教科書的由中國人建立的學科領域。在應用方面，發明翻譯暫停理性重設計法優化蛋白質可溶性表達效率，可在氨基酸序列、表達條件完全不變的前提下，將蛋白質可溶性表達產率提高數千倍，為生化工程提供全新的可能性。
| 1 | Zhang, G., & Ignatova, Z.*, A generic algorithm to predict the speed of translational elongation: implications for protein biogenesis. PLoS One, 4(4):e5036 (2009). |
| 2 | Zhang, G., & Ignatova, Z.*, Isolation of homogenous ribosome-nascent-chain complexes from coupled cell-free transcription-translation system. Nature Protocols doi:10.1038/nprot.2009.47 (2009). |
| 3 | Zhang, G., Hubalewska, M., & Ignatova, Z.*, Transient ribosomal attenuation coordinates protein synthesis and co-translational folding. Nat Struct Mol Biol, 16(3):274-80 (2009). |
| 4 | Czech, A., Fedyunin, I., Zhang, G. & Ignatova, Z.*, Silent mutations in sight: Co-variations in tRNA abundance as key to unravel consequences of silent mutations. Molecular Biosystems. 2010 Oct 1;6(10):1767-72 |
| 5 | Zhang, G., Fedyunin, I., Miekley, O., Valleriani, A., Moura A. & Ignatova, Z.*, Global and local depletion of ternary complex limits translational elongation. Nucleic Acid Res, (2010) 38(14):4778-87 |
| 6 | Valleriani, A.*, Zhang, G., Nagar, A., Ignatova, Z., Length dependent translation of messenger RNA by ribosomes, Physical Review E, 83(4 Pt 1):042903 (2011) |
| 7 | Borwankar, T., Rötlein, C., Zhang, G., Techen, A., Dosche, C. & Ignatova, Z.*, Natural osmolytes remodel the aggregation pathway of mutant Huntingtin exon 1. Biochem. 29;50(12):2048-60 (2011). |
| 8 | Zhang, G., Lukoszek, R., Mueller-Roeber, B., Ignatova, Z.*, Different sequence signatures in the upstream regions of plant and animal tRNA genes shape distinct modes of regulation. Nucleic Acid Res. (2011) 39(8):3331-9 |
| 9 | Zhang, G. & Ignatova, Z.*, Folding at the birth of the nascent chain: Coordinating translation with co-translational folding. Current Opinion of Structural Biology, (2011) 21:25-31. |
| 10 | CL Xiao, XZ Chen, YL Du, ZF Li, L Wei, G Zhang *, QY He *, Dispec: A Novel Peptide Scoring Algorithm Based on Peptide Matching Discriminability, PLoS One (2013) 8 (5), e62724 |
| 11 | Wang T *, Cui Y, Jin J, Guo J, Wang G, Yin X, He QY *, Zhang G * , Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific. Nucleic Acids Res. (2013) 41(9):4743-54 |
| 12 | Xiao CL, Chen XZ, Du YL, Sun X, Zhang G*, He QY.* Binomial Probability Distribution Model-Based Protein Identification Algorithm for Tandem Mass Spectrometry Utilizing Peak Intensity Information. J. Proteome Res. (2013) 12 (1), 328–335 |
| 13 | Fedyunin I, Lehnhardt L, Böhmer N, Kaufmann P, Zhang G, Ignatova Z*, tRNA concentration fine tunes protein solubility. FEBS Lett. (2012) |
| 14 | Zhang, G.*, Fedyunin, I., Kirchner, S., Xiao, C., Valleriani, A. & Ignatova, Z.*, FANSe: an accurate algorithm for quantitative mapping of large scale sequencing reads. Nucleic Acid Res. (2012) 40(11):e83. |
| 15 | Hinz J., Lehnhardt L., Zakrzewski S., Zhang G., Ignatova Z.*, Polyglutamine expansion alters the dynamics and molecular architecture of aggregates in dentatorubropallidoluysian atrophy, J Biol Chem. (2012) 13;287(3):2068-78. |
| 16 | Chen W, Jin J, Gu W, Wei B, Lei Y, Xiong S *, Zhang G *. Rational design of translational pausing without altering the amino acid sequence dramatically promotes soluble protein expression: A strategic demonstration. Journal of Biotechnology (2014), 189(10), 104-113 |
| 17 | Puri P, Wetzel C, Saffert P, Gaston KW, Russell SP, Varela JA, van der Vlies P, Zhang G, Limbach PA, Ignatova Z, Poolman B *, Systematic identification of tRNAome and its dynamics in Lactococcus lactis. Molecular Microbiology (2014), 93(5), 944-956 |
| 18 | Chen M, Liu T, Xu L, Gao X, Liu X, Wang C, He Q, Zhang G, Liu L *, Direct Interaction of 14-3-3ζ with Ezrin Promotes Cell Migration by Regulating the Formation of Membrane Ruffle. Journal of Molecular Biology (2014), 426(18), 3118-3133 |
| 19 | X Wu, L Xu, W Gu, Q Xu, QY He *, X Sun *, G Zhang * Iterative Genome Correction Largely Improves Proteomic Analysis of Nonmodel Organisms. Journal of proteome research (2014), 13 (6), 2724–2734 |
| 20 | CL Xiao, ZB Mai, XL Lian, JY Zhong, JJ Jin, QY He *, G Zhang *, FANSe2: A Robust and Cost-Efficient Alignment Tool for Quantitative Next-Generation Sequencing Applications, PLoS One (2014), 9(4):e94250 |
| 21 | L Zhang, HL Jia, et al., Monitoring of the serum proteome in Kawasaki disease patients before and after immunoglobulin therapy, Biochemical and Biophysical Research Communications (2014), 447(1), 19-25 |
| 22 | G Zhang *, T Wang *, QY He *, How to discover new proteins—translatome profiling, （中文版: 怎樣發現未知蛋白質——翻譯組測序） Science China Life Sciences (2014) 57 (3), 358-360 |
| 23 | C Chang, L Li, et al., Systematic analyses of the transcriptome, translatome, and proteome provide a global view and potential strategy for the C-HPP, Journal of proteome research (2014) 13 (1), 38-49 |
| 24 | Q Wang, B Wen, et al., Omics Evidence: Single Nucleotide Variants Transmissions on Chromosome 20 in Liver Cancer Cell Lines, Journal of proteome research (2014) 13 (1), 200-211 |
| 25 | Y Liu, W Ying, et al, Chromosome-8-Coded Proteome of Chinese Chromosome Proteome Data Set (CCPD) 2.0 with Partial Immunohistochemical Verifications, Journal of proteome research (2014) 13 (1), 126-136 |
| 26 | C Zhang, N Li, et al., Systematic analysis of missing proteins provides clues to help define all of the protein-coding genes on human chromosome 1, Journal of proteome research (2014) 13 (1), 114-125 |
| 27 | J Zhong, Y Cui, J Guo, Z Chen, L Yang, QY He, G Zhang *, T Wang *, Resolving Chromosome-Centric Human Proteome with Translating mRNA Analysis: A Strategic Demonstration, Journal of proteome research (2014) 13 (1), 50-59 |
| 28 | Fan X, Xiong H, Wei J, Gao X, Feng Y, Liu X, Zhang G, He QY * Xu J *, Liu L *. Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation . Scientific Reports (2015) 5:17732. |
| 29 | Luo B, Gu W, Zhong J, Wang Y *, Zhang G *. Revealing crosstalk of plant and fungi in the symbiotic roots of sewage-cleaning Eichhornia crassipes using direct de novo metatranscriptomic analysis. Scientific Reports (2015) 5:15407. |
| 30 | Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F *, He QY *, Zhang G *, Wang T *. Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria. Journal of Proteome Research (2015) 14(9):3645-57 |
| 31 | Chen Y, Li Y, Zhong J, Zhang J, Chen Z, Yang L, Cao X, He QY *, Zhang G *, Wang T *. Identification of missing proteins defined by chromosome-centric proteome project in the cytoplasmic detergent-insoluble proteins. Journal of Proteome Research (2015) 14(9):3693-709 |
| 32 | Zhong J, Xiao C, Gu W, Du G, Sun X, He QY *, Zhang G *. Transfer RNAs Mediate the Rapid Adaptation of Escherichia coli to Oxidative Stress. PLoS Genetics (2015) 11(6):e1005302 |
| 33 | Guo J, Lian X, Zhong J, Wang T *, Zhang G *. Length-dependent translation initiation benefits the functional proteome of human cells. Molecular BioSystems (2015) 11, 370-378 |
| 34 | Chen Z, Yang L, Cui Y, Zhou Y, Yin X, Guo J, Zhang G *, Wang T *, He QY *. Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages. Oncotarget (2016) doi: 10.18632/oncotarget.11794. |
| 35 | Guo J, Cui Y, Yan Z, Luo Y, Zhang W, Deng S, Tang S, Zhang G, He QY *, Wang T *. Phosphoproteome Characterization of Human Colorectal Cancer SW620 Cell-Derived Exosomes and New Phosphosite Discovery for C-HPP. Journal of Proteome Research (2016) doi: 10.1021/acs.jproteome.6b00391 |
| 36 | Lian X, Guo J, Gu W, Cui Y, Zhong J, Jin J, He QY *, Wang T *, Zhang G *. Genome-wide and experimental resolution of relative translation elongation speed at individual gene level in human cells. PLoS Genetics (2016) 12(2): e1005901. |
| 37 | Bartholomäus A, Fedyunin I, Feist P, Sin C, Zhang G, Valleriani A, Ignatova Z *. Bacteria differently regulate mRNA abundance to specifically respond to various stresses. Phil. Trans. R. Soc. A (2016) 374:20150069. |
| 39 | Yang XY, He K, Du G, Wu X, Yu G, Pan Y, Zhang G *, Sun X *, He QY *. Integrated Translatomics with Proteomics to Identify Novel Iron–Transporting Proteins in Streptococcus pneumoniae. Front. Microbiol. (2016) 7:78. |
| 40 | Zhao P, Zhong J, Liu W, Zhao J, Zhang G *. Protein-Level Integration Strategy of Multiengine MS Spectra Search Results for Higher Confidence and Sequence Coverage. Journal of Proteome Research (2017) 16(12), 4446–4454. |
| 41 | 曹欣，張弓 * 超高精度大規模測序mapping演演算法FANSe在非模式生物中的應用 【綜述】 中國科學·生命科學 (2017), 47. doi: 10.1360/N052016-00280 Cao X, Zhang G *. Application of the hyper-accurate mapping algorithm FANSe for next-generation sequencing in non-model organisms Sci Sin Vitae, 2017, 47, doi: 10.1360/N052016-00280 |
| 42 | 曹欣，劉婉婷，張弓 * 非模式細菌功能基因組獲取策略比較 基因組學與應用生物學 (2017), 36(7): 1-8. |
| 43 | Wang C, Chen K, Liao S, Gu W, Lian X, Zhang J, Gao X, Liu X, Wang T, He QY *, Zhang G *, Liu L *. The flightless I protein interacts with RNA-binding proteins and is involved in the genome-wide mRNA post-transcriptional regulation in lung carcinoma cells. International Journal of Oncology (2017) doi: 10.3892/ijo.2017.3995. |
| 44 | Mai Z, Xiao C, Jin J, Zhang G *. Low-cost, Low-bias and Low-input RNA-seq with High Experimental Verifiability based on Semiconductor Sequencing. Scientific Reports (2017) 7:1053. |
| 45 | 趙晶，張弓 * 翻譯組學：方法及應用 【綜述】 生命的化學 (2017), 37(1): 70-79. doi: 10.13488/j.smhx.20170111 |
| 46 | Jia HL, Liu CW, Zhang L, Xu WJ, Gao XJ, Bai J, Xu YF, Xu M *, Zhang G *. Sets of serum exosomal microRNAs as candidate diagnostic biomarkers for Kawasaki disease. Scientific Reports (2017) 7:44706. |
| 47 | Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Yang X, Huang N, Zhou H, Liu J, He K, Xie K, Zhang G, Huang S, Zhang N *. A Peptide Encoded by Circular Form of LINC-PINT Suppresses Oncogenic Transcriptional Elongation in Glioblastoma Nature Communications (2018) 9, 4475. |
| 48 | Li D, Lu S, Liu W, Zhao X, Mai Z, Zhang G *. Optimal settings of mass spectrometry open search strategy for higher confidence Journal of Proteome Research (2018) 17(11), 3719-3729. |
| 49 | Wu Q, Tian Y, et al. In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis. PNAS (2018) 115 (17), E3978-E3986. |
| 50 | Cao K, Wang H, Li N, Cao X, He J, Zhang B, He QY *, Zhang G *, Sun X *. Two zinc-binding domains in the transporter AdcA from Streptococcus pyogenes facilitate high-affinity binding and fast transport of zinc. Journal of Biological Chemistry (2018) 293 (16), 6075-6089. |
| 51 | Bao X, Guo X, et al. Capturing the Interactome of Newly Transcribed RNA. Nature Methods (2018) 15, 213-220. |
| 52 | Huang W, Liu W, Jin J, Xiao Q, Lu R, Chen W, Xiong S *, Zhang G *. Steady-state structural fluctuation is a predictor of the necessity of pausing-mediated co-translational folding for small proteins. Biochem Biophys Res Commun (2018) 498(1), 186-192. |
| 53 | Liu W, Xiang L, Zheng T, Jin J, Zhang G *. TranslatomeDB: a comprehensive database and cloud-based analysis platform for translatome sequencing data. Nucleic Acids Research (2018) 46(D1), D206-212. |
| 54 | Lu S, Zhang J, Lian XL, Sun L, Meng K, Chen Y, Sun Z, Yin X, Li Y, Zhao J, Wang T *, Zhang G *, He QY * A Hidden Human Proteome Encoded by “Non-Coding” Genes Nucleic Acids Research (2019) 47 (15), 8111-8125. |
| 55 | Mai Z, Liu W, Ding W, Zhang G * Misassembly of long reads undermines de novo assembled ethnicity-specific genomes: Validation in a Chinese Han Population Human Genetics (2019) https://doi.org/10.1007/s00439-019-02032-6. |
| 56 | Zhao J, Zhang H, Qin B, Nikolay R, He QY, Spahn CMT *, Zhang G * Multifaceted stoichiometry control of bacterial operons revealed by data-independent acquisition mass spectrometry Frontiers in Genetics (2019) 10:473. |
| 57 | Shi T, Wei Q, Wang Z, Zhang G *, Sun X *, He QY * Photocatalytic protein damage by silver nanoparticles circumvents bacterial stress response and multidrug resistance mSphere (2019) 4(3), e00175-19. |
| 58 | Sun Y, Cai M, Zhong J, Jin F, Xiao J, Yang L, Wang Y, Zhang Q, Wang Z *, Zhang G *, Wang X * A long noncoding RNA lnc-ob1 facilitates bone formation by upregulating Osterix in osteoblasts Nature Metabolism (2019) 1, 485–496 (2019). |
| 59 | Gao L, Hu Y, et al. Lung Cancer Deficient in the Tumor Suppressor GATA4 are Sensitive To TGFBR1 Inhibition Nature Communications (2019) 10:1665. |
| 60 | Liao X, Zhao J, Liang S, Jin J, Li C, Xiao R, Li L, Guo M, Zhang G *, Lin Y *. Enhancing co-translational folding of heterologous protein by deleting non-essential ribosomal proteins in Pichia pastoris Biotechnology and Biofuels (2019) 12:38. |
| 61 | Zhao J, Qin B, Nikolay R, Spahn CMT, Zhang G *. Translatomics: The Global View of Translation International Journal of Molecular Sciences (2019) 20(1), 212. |
| 62 | Zhou Z #, Yang Z #, Ou J #, Zhang H, Zhang Q *, Dong M *, Zhang G * Temperature Dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome Computational and Structural Biotechnology Journal (2020) 19:161-167. |
| 63 | Lin H #, Zhang G #, Zhang XC #, Lian X, Su J, Chen SL, Wu YL * Germline Variation Networks in the PI3K/AKT Pathway Corresponding to Familial High-incidence Lung Cancer Pedigrees BMC Cancer (2020) 9;20(1):1209. |
| 64 | Li D *, Liu B, Zheng H, Xiao X, Li Z, Luan E, Li W, Wang Y, Yang Y, Long Q, Song J, Zhang G * XY-Meta: A high-efficiency search engine for large scale metabolome annotation with accurate FDR estimation Analytical Chemistry (2020) 92:8, 5701-5707. |
| 65 | Lu S, Wang T, Zhang G, He QY * Understanding the proteome encoded by “non-coding RNAs”: New insights into human genome Science China Life Sciences (2020) 1-10. |
| 66 | Zhang G *, Zhang Y, Jin J * The Ultrafast and Accurate Mapping Algorithm FANSe3: Mapping a Human Whole-Genome Sequencing Dataset Within 30 min Phenomics (2021) 1, 22–30 . |
| 67 | Ou J, Zhou Z, Dai R, Zhang J, Zhao S, Wu X, Lan W, Ren Y, Cui L, Lan Q, Lu L, Seto D, Chodosh J, Wu J, Zhang G *, Zhang Q * V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity Journal of Virology (2021) 95(16):e0061721. |
| 68 | Man Zhang, Jing Zhao, Wanying Li, Shuqi Wen, Huiling Huang, Jie Dong, Bing Liu, Gong Zhang, Hong-Bin Wang, Yanting Shen *, Hong-Lei Jin * Increased photosystem II translation efficiency as an important photoprotective mechanism in an Arabidopsis thaliana ecotype (Tibet-0) adapted to high light environments Environmental and Experimental Botany (2021) 183:104350. |
| 69 | Yixi Li, Dehua Li, Yang Chen, Yongping Lu, Fangbin Zhou, Chunhong Li, Zhipeng Zeng, Wanxia Cai, Liewen Lin, Qiang Li, Mingjun Ye, Jingjing Dong, Lianghong Yin *, Donge Tang *, Gong Zhang *, Yong Dai * Robust Glycogene-Based Prognostic Signature for Proficient Mismatch Repair Colorectal Adenocarcinoma Frontiers in Oncology (2021) 11:727752. |
| 70 | Huiying Fang, Guandi Zeng, Jing Zhao, Tingkai Zheng, Lina Xu, Wei Gu, Yutong Liu, Jinning Zhang, Xuesong Sun *, Gong Zhang * Genome recombination-mediated tRNA up-regulation conducts general antibiotic resistance of bacteria at early stage Frontiers in Microbiology in press. |
| 71 | 方慧穎，張弓 * 及與翻譯調控的細菌耐葯研究進展 微生物學通報 (2022) in press. |
1、表達量高和活性強的CVN突變體的編碼序列及其應用，國家發明專利（已授權），201310164451.4，發明人：陳偉、張弓、熊盛、金靜潔，2014。
2、通過翻譯暫停序列理性重設計改善蛋白質可溶性表達的方法，國家發明專利（已授權），201310164454.8，發明人：張弓、陳偉、熊盛、金靜潔，2015。
4、完整獲取組織內核糖體新生肽鏈複合物的方法，國家發明專利（已授權），201410452522.5，發明人：孫黎、張弓、王通、金靜潔，2017。
國家級青年人才，省級青年人才。
廣東省黨外知識分子聯誼會理事，深圳市龍華區第一屆政協常委、高層次人才促進會會長、龍華區總商會常務理事。
基本信息
- 中文名
- 張弓
- 性別
- 男
- 職業
- 教師
- 畢業院校
- 波茨坦大學
- 任職機構
- 暨南大學生命科學技術學院
- 最高學位
- 博士
- 職稱
- 研究員
- 研究領域
- 翻譯組學、生物信息學與系統生物學