黃百渠
黃百渠
黃百渠,東北師範大學生命科學學院教授,博士生導師。1986年獲英國愛丁堡大學博士學位。現任東北師範大學遺傳與細胞研究所所長,先後曾兼任中國細胞生物學常務理事、中國遺傳學會常務理事、國務院學位委員會學科評議組成員、國家自然科學基金委員會專家組成員、教育部生物教學指導委員會委員等職;第八、九、十屆全國人大代表。2010年起任吉林省人民政府參事。
1992年起享受國務院政府特殊津貼。
1994年獲吉林省委省政府頒發的英才獎章。
1996年獲國家人事部和國家教委授予的“全國優秀留學回國人員”稱號。
1997年獲得華為優秀教師獎。
1998年被評為全國教育系統勞動模範並獲全國模範教師稱號。
1998年、2002年分別被評為吉林省省管優秀專家。
1998年被評為吉林省有突出貢獻的中青年科技專家。
1999年被聘為首批“長江學者獎勵計劃”特聘教授。從事細胞生物學和分子生物學的教學與科研工作,先後主持國家“863”計劃、國家“攀登計劃”、國家重點基礎研究發展規劃項目(973)、國家自然科學基金、國家教育部及吉林省近二十項科研任務。
2000年被評為吉林省“師德標兵”;
2002年被評為長春市勞動模範。
開展真核基因表達調控、分子表觀遺傳學、基因工程和細胞工程、抗癌新葯的研製以及中藥現代化等研究工作,獲得了一系列科研成果。曾獲國家自然科學獎三等獎一項,國家教育部科技進步一、二等獎各一項,中國高校科學技術二等獎一項,中國高校自然科學一等獎一項,吉林省教委科技進步獎兩項,吉林省高等教學成果獎一等獎一項、吉林省高等教育教學成果特等獎一項。在國內外重要學術刊物上發表論文近100篇,出版專著一部,編著三部,主編教材二部。
1973-1976:東北師範大學生物系,學生
1976-1978:遼源礦務局第四中學,教師
1981-1982:東北師範大學生物系,教師
1982-1986:英國愛丁堡大學植物學系,博士研究生,獲博士學位(Ph.D.)
1986-1992:東北師範大學遺傳與細胞研究所副所長
1989年任副教授,1991年被破格晉陞為教授
1992-1994:美國密西根癌症研究基金會,博士后
1993年被國務院學位委員會批准為博士生導師
1994-至今:東北師範大學遺傳與細胞研究所所長
1999年被聘為首批“長江學者獎勵計劃”特聘教授
1993年被選為第八屆全國人民代表大會代表
1998年被選為第九屆全國人民代表大會代表
2003年被選為第十屆全國人民代表大會代表
1997年起任第四屆國務院學位委員會學科評議組成員
2006年起任東北師範大學自然科學學術委員會主任
2010年起任吉林省人民政府參事
2016年1月,續聘為吉林省政府參事
本科:《細胞生物學》、《現代生命科學系列講座》(其中之一)
博士研究生:分子生物學、動物基因工程、真核基因表達調控
指導博士、碩士研究生20餘人。
1.植物細胞生物學和遺傳學高質量研究生的培養。1996,吉林省高等教學成果獎一等獎(排名第三)
2. 立足東北輻射全國的新型生物學人才培養基地的建設。2005,吉林省高等教育省級教學成果特等獎(排名第二)
3. “細胞生物學”課程被評為國家級精品課。2006,(排名第一)
4,吉林省優秀教學團隊(細胞生物學)。2007,(排名第一)
5,“細胞生物學”國家優秀教學團隊。2009,(排名第一)
分子生物學、細胞生物學及遺傳學。
近年來主持的主要科研項目:
2,真核染色質和基因轉錄中的分子作用及構象研究(1999-2002),國家自然科學基金項目,經費12萬元。已完成
4,基因工程生產啤酒工業用α-乙醯乳酸脫羧酶(α-ALDC)製劑(2001-2004),吉林省計劃委員會生物技術產業化專項重點項目,經費30萬元,已完成。
6,中藥配伍理論的物質基礎研究(2003-2005),國家中醫藥管理局項目,經費5萬元,已完成。
7,抗SARS病毒天然藥物的篩選(2003-2004 ),吉林省科技廳重點項目,經費20萬元,已完成。
8,人Elongator複合物在真核生物基因表達調控中功能研究(2003-2006),國家自然科學基金項目(項目批准號:30370316),經費21萬元。已完成。
9,大豆蜜腺組織特異表達啟動子的獲得及功能研究(2004-2005),國家轉基因植物研究與產業化開發專項課題,經費12萬元。已完成。
11, 染色質重塑和可逆乙醯化修飾在白細胞介素5(IL-5)基因轉錄調控中的作用機制研究(2005-2008),國家自然科學基金項目(項目批准號:30571698),經費28萬元。在研究中。
12,禽流感快速檢測技術的建立及H5、H7亞型禽流感二價基因工程疫苗的研製(2006-2008)。國家教育部重大項目(項目批准號:306006),經費100萬元。在研究中。
14,過表達BMP4促進腫瘤細胞過早性衰老及機制研究。(2007-2010)國家自然科學基金項目(項目批准號:30771232),經費30萬元。在研究中。
15,抗腫瘤中藥有效成分的篩選及新葯創製。(2007-2009)吉林省科技廳重大項目,經費100萬元。在研究中。
16,前列腺癌細胞中HOXB13基因沉默的表觀遺傳調控機制研究。(2010-2012)國家自然科學基金項目(項目批准號:30971613),經費34萬元。在研究中。
17,間充質幹細胞成骨分化中VDR 及其靶基因參與表觀遺傳學調控機制的研究。(2011-2013)國家自然科學基金重大研究計劃項目(項目批准號:91019011),經費60萬元。在研究中。
18,精氨酸甲基化酶PRMT7通過EMT過程促進乳腺癌轉移機制的研究。(2012-2015)國家自然科學基金項目(項目批准號:31170719),經費55萬元。在研究中。
近年來發表的主要SCI論文:
2012年:
Juan Du, Lin Li, Zhouluo Ou, Chenfei Kong, Yu Zhang, Zhixiong Dong, Shan Zhu, Hao Jiang, Zhimin Shao, Baiqu Huang*, Jun Lu*, 2012, FOXC1, a target of polycomb, inhibits metastasis of breast cancer cells. Breast Cancer Research and Treatment 131(1):65-73 (SCI收錄)
2011年:
Yu Zhang, Yanyan Gao, Guoping Zhang, Shuyan Huang, Zhixiong Dong, Chenfei Kong, Dongmei Su, Juan Du, Shan Zhu, Qian Liang, Jianchao Zhang, Jun Lu and Baiqu Huang, 2011, DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. International Journal of Cancer 128:551-561(SCI收錄)
Zhixiong Dong, Ruikang Tan, Jian Cao, Yang Yang, Chenfei Kong, Juan Du, Shan Zhu, Yu Zhang, Jun Lu, Baiqu Huang*, Shuxia Liu*, 2011, Discovery of polyoxometalate-based HDAC inhibitors with profound anticancer activity in vitro and in vivo. European Journal of Medicinal Chemistry 46(6):2477-2484 (SCI收錄)
Chenfei Kong, Changqing Wang, Liping Wang, Musong Ma, Chunbo Niu, Xiaoqian Sun, Juan Du, Zhixiong Dong, Shan Zhu, Jun Lu, Baiqu Huang*, 2011, NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PLoS ONE 6(7): e22666 (July, 28th, 2011)(SCI收錄)
Matloob Ammar, Pan Lina, Pan Hong, Lu Jun, Huang Baiqu*, 2011, SMAD-4 cooperates with TGF-β to enhance PTEN expression upon the inhibition of RAS/ERK pathway in gastric carcinoma cells. Progress in Biochemistry and Biophysics 38(6):543-550 (SCI收錄)
Xin Zhou, Shu-Yan Huang, Jing-Xin Feng, Yan-Yan Gao, Li Zhao, Jun Lu, Bai-Qu Huang, Yu Zhang*, 2011, SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells. World Journal of Gastroenterology 17(44): 4922-4927 (SCI收錄)
2010年:
Dongmei Su, Xiue Peng, Shan Zhu, Ying Huang, Zhixiong Dong, Yu Zhang, Jianchao Zhang, Qian Liang, Jun Lu*, Baiqu Huang*, 2010, Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung caner cells. Biochemical Journal 433(2):333-343(SCI收錄)
L. Pan, J. Du, H. Pan, Ammar F. Matloob, Z. Dong, J. Zhao, Y. Feng, . Zhong, B. Huang, J. Lu, 2010, Vitamin D stimulates apoptosis in gastric cancer cells in synergy with TSA/NaBu- and 5-Aza-induced PTEN upregulation. FEBS Journal 277: 989-999 (SCI收錄)
Xiuli Wang, Yunpeng Feng, Jing Zhao, Hong Pan, Baiqu Huang, Jun Lu, 2010, The expression of p16 is regulated by the reversible histone acetylation. Progress in Biochemistry and Biophysics 36(6):600-606 (SCI收錄)
Lina Pan, Hong Pan, Hao Jiang, Juan Du, Xiuli Wang, Baiqu Huang, Jun Lu, 2010, HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1. Cellular and Molecular Immunology 7(3):221-226 (SCI收錄)
Hanqing Shi, Hui Huang, Xitao Zhang, Jianchao Zhang, Xiutan Luo, Xiue Peng, Baiqu Huang, Jun Lu, 2010, c-Myc attenuates the ability of doxorubicin to reduce the colony formation partially through regulating Nbs1 in U2OS cells. Progress in Biochemistry and Biophysics 37(8):855-863 (SCI收錄)
2009年:
Dongmei Su, Shan Zhu, Xuefang Han, Yunpeng Feng, Hui Huang, Guoling Ren, Lina Pan, Yu Zhang, Jun Lu*, Baiqu Huang*, 2009, BMP4-Smad signal pathway mediates Adriamycin-induced premature senescence in lung cancer cells. Journal of Biological Chemistry 284(18): 12153-12164 (SCI收錄)
Jiang Tan, Jun Lu, Wei Huang, Zhixiong Dong, Chenfei Kong, Lin Li, Lina Gao, Jianhua Guo*, Baiqu Huang*, 2009, Genome-wide Analysis of Histone H3 Lysine9 Modifications in Human Mesenchymal Stem Cell Osteogenic Differentiation. PLoS One 4(8):e6792 (SCI收錄)
Guoling Ren, Guocui Zhang, Zhixiong Dong, Zhiwei Liu, Lin Li, Yunpeng Feng, Dongmei Su, Yu Zhang, Baiqu Huang, Jun Lu, 2009, Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. The International Journal of Biochemistry & Cell Biology 41(5):1094-1101 (SCI收錄)
Yu Zhang, Shuyan Huang, Wei Dong, Lin Li, Yunpeng Feng, Lina Pan, Zhenkun Han, Xiuli Wang, Guoling Ren, DongmeiI Su, Baiqu Huang, Jun Lu, 2009, SOX7 is down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. Cancer Letters 277(1):29-37 (SCI收錄)
Tian Li, Hui Huang, Binlu Huang, Baiqu Huang, Jun Lu, 2009, Histone Acetyltransferase p300 Regulates the Expression of Human Pituitary Tumor Transforming Gene (hPTTG). Journal of Genetics and Genomics 36(6):335-342(SCIE收錄)
Feng Y, Wang X, Xu L, Pan H, Zhu S, Liang Q, Huang B, Lu J., 2009, The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence. FEBS Journal 276(15):4197-206 (SCI, IF=3.139)
2008年:
Qiuju Han, Jun Lu, Jizhou Duan, Dongmei Su, Xiaozhe Hou, Fen Li, Xiuli Wang, Baiqu Huang, 2008, Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Biochemical Journal 409(3):779-788 (SCI收錄)
Xiuli Wang, Lina Pan, Yunpeng Feng, Yanle Wang, Qiuju Han, Liping Han,Songyan Han, Jianhua Guo, Baiqu Huang, Jun Lu, 2008, p300 plays a role in p16INK4a expression and cell cycle arrest. Oncogene 27:1894-1904 (SCI收錄)
Yichun Liu, Mingya Zhong, Guiye Shan, Yajun Li, Baiqu Huang and Guoliang Yang, 2008, Biocompatible ZnO/Au Nanocomposites for Ultrasensitive DNA Detection Using Resonance Raman Scattering. J. Phys. Chem. B 112:6484–6489 (SCI收錄)
Xiuli Wang, Yunpeng Feng, Liang Xu, Yuli Chen, Yu Zhang, Dongmei Su, Guoling Ren, Jun Lu, Baiqu Huang, 2008, YY1 restrained cell senescence through repressing the transcription of p16. Biochimica et Biophysica Acta-Mol. Cell Res. (in press) (SCI收錄)
Liping Han, Yun Zhong, Binlu Huang, Limei Han, Lina Pan, Xin Xu, Xiuli Wang, Baiqu Huang, Jun Lu, 2008, Sodium butyrate activates erythroid-specific 5-aminolevulinate synthase gene through Sp1 elements at its promoter. Blood Cells, Molecules, and Diseases (in press) (SCI收錄)
2007年:
Songyan Han, Jun Lu, Yu Zhang, Cao Cheng, Lin Li, Liping Han, Baiqu Huang, 2007, HDAC inhibitors TSA and sodium butyrate enhanced the human IL-5 expression by altering histone acetylation status at its promoter region. Immunology Letters 108:143-150 (SCI收錄)
Lina Pan, Jun Lu, Xiuli Wang, Liping Han, Yu Zhang, Songyan Han, Baiqu Huang, 2007, Histone deacetylase inhibitor Trichostatin A potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. Cancer 109(8):1676-1688 (SCI收錄)
Xiuli Wang, Yunpeng Feng, Lina Pan, Yanle Wang, Xin Xu, Jun Lu, Haiqu Huang, 2007, The proximal GC-rich region of p16INK4a gene promoter plays a role in its transcriptional regulation. Molecular and Cellular Biochemistry 301(1-2):259-266 (SCI收錄)
Qiuju HAN, Xiaozhe HOU, Dongmei SU, Lina PAN, Jizhou DUAN, Liguo CUI, Baiqu HUANG, and Jun LU, 2007, hELP3 Subunit of the Elongator Complex Regulates the Transcription of HSP70 Gene in Human Cells. Acta Biochemica et Biophysica Sinica 39(6):453-461 (SCIE收錄)
Xiaojuan Zhu, Baiqu Huang, Xingzhi Wang, Shui Hao, Xianlu Zeng, 2007, Actin and myosin I are associated with RNAP II and function in gene transcription. Chinese Science Bulletin 52(6):766-770 (SCI收錄)
Yanmei Zhao, Jun Lu, Hui Sun, Xia Chen, Baiqu Huang, 2007, Roles of histone acetylation modification in basal and inducible expression of hsp26 gene in D. melanogaster. Molecular and Cellular Biochemistry 306(1-2):1-8 (SCI收錄)
Lina Pan, Jun Lu, Baiqu Huang, 2007, HDAC inhibitors: A new category of anti-tumor agents.(invited review) Cellular and Molecular Immunology 4(5):337-343 (SCI收錄)
Yangguang SHAO, Jun LU, Cao CHENG, Liguo CUI,Guoping ZHANG, and Baiqu HUANG, 2007, Reversible histone acetylation is involved in transcriptional regulation of WT1 gene. Acta Biochemica et Biophysica Sinica 39(12):931-938 (SCIE收錄)
2006年:
Weifeng Huang, Dapeng Tan, Xiuli Wang, Songyan Han, Jiang Tan, Yanmei Zhao, Jun Lu, Baiqu Huang, 2006, Histone deacetylase 3 represses p15INK4b and p21WAF1/cip1 transcription by interacting with Sp1. Biochemical and Biophysical Research Communications 339:165-171 (SCI收錄)
Haijing Sun, Xin Xu, XiuLi Wang, Liang Wei, Fen Li, Jun Lu, Baiqu Huang, 2006, Transcription factors Ets2 and Sp1 act synergistically with histone acetyltransferase p300 in activating human Interleukin-12 p40 promoter. Acta Biochemica et Biophysica Sinica 38(3):194-200(SCIE收錄)
Yanmei Zhao, Jun Lu, Xia Chen, Hui Sun, Zhigen Yuan, Guoling Ren, Xiaoxue Li, Baiqu Huang, 2006, Effects of histone deacetylase inhibitors on transcriptional regulation of hsp70 gene in Drosophila. Cell Research 16(6):566-576(SCI收錄)
Liping Han,Jun Lu,Lina Pan,Xiuli Wang,Yangguang Shao,Songyan Han, Baiqu Huang,2006, Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene. Biochemical and Biophysical Research Communications 348:799-806 (SCI收錄)
Songyan Han, Jun Lu, Yu Zhang, Cao Cheng, Liping Han, Xiuli Wang, Lin Li, Chunyan Liu , Baiqu Huang, 2006, Recruitment of Histone Deacetylase 4 by Transcription Factors Represses Interleukin-5 Transcription. Biochemical Journal 400(3):439-448 (SCI收錄)
2005年:
Yanmei Zhao, Jun Lu, Hui Sun, Xia Chen, Weifeng Huang, Dan Tao, Baiqu Huang, 2005, Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila. Biochemical and Biophysical Research Communications 326:811-816 (SCI收錄)
Haijing Sun, Jun Lu, Xin Xu, Shunzi Jin, Xiuli Wang, Liang Wei, Mei Dong, Baiqu Huang, 2005, Histone acetyltransferase activity of p300 enhances the activation of IL-18 promoter. Journal of Cellular Biochemistry 94(3):566-572 (SCI收錄)
Yanmei Zhao, Hui Sun, Jun Lu, Xiaoxue Li, Xia Chen, Dan Tao, Weifeng Huang, Baiqu Huang, 2005, Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylases inhibitors. Journal of Experimental Biology 208(4):697-705 (SCI收錄)
Yangguang Shao, Jun Lu, Guoping Zhang, Chunyan Liu, and Baiqu Huang , 2005, Histone acetyltransferase p300 promotes the activation of human WT1 promoter and intronic enhancer. Archives of Biochemistry and Biophysics 436(1):62-68 (SCI收錄)
Fen Li, Jun Lu, Qiuju Han, Guoping Zhang, and Baiqu Huang, 2005, The Elp3 subunit of human Elongator complex is functionally similar to its counterpart in yeast. Molecular Genetics and Genomics 273(3):264-272 (SCI收錄)
Jun Lu, Haijing Sun, Xiuli Wang, Chunyan Liu, Xin Xu, Fen Li, Baiqu Huang, 2005, Interleukin-12 p40 promoter activity is regulated by the reversible acetylation mediated by HDAC1 and p300. Cytokine 3(1):46-51(SCI收錄)
Xiaoxue Li, Jun Lu, Yanmei Zhao, Baiqu Huang, 2005, Ras protein participated in histone acetylation-mediated cell cycle control in Physarum polycephalum. Chinese Science Bulletin 50(16):1721-1725(SCI收錄)
Xiaoxue Li, Jun Lu, Hui Sun, Yanmei Zhao, Xiuli Wang, Dan Tao, Baiqu Huang, 2005, Function of c-Fos-like and c-Jun-like proteins on TSA-induced G2/M arrest in Physarum polycephalum. Acta Biochemica et Biophysica Sinica 37(11):767-772(SCIE收錄)
2004年:
Chunyan LIU, Jun LU, Lin LI, Jiang TAN, Yangguang SHAO, Baiqu HUANG, 2004, Coactivator CBP/p300 increased the activity of C/EBP-mediated human interleukin-5 gene promoter. Chinese Science Bulletin 49(6):574-578 (SCI收錄)
Min Wei, Guihua Tai, Yanguang Gao, Na Li, Baiqu Huang, Yifa Zhou, Shui Hao, and Xianlu Zeng, 2004, Modified heparin inhibit P-selectin- mediated cell adhesion of human colon carcinoma cells to immobilized platelets under dynamic flow conditions. Journal of Biological Chemistry 279(28): 29202–29210(SCI收錄)
Haijing Sun, Jun Lu, Xin Xu, Liang Wei, Baiqu Huang, 2004, Reversible histone acetylation/deacetylation modification by p300 and HDAC3 is involved in the regulation of IL-18 promoter activity. Chinese Science Bulletin 49(11):1151-1156 (SCI收錄)
Chunyan Liu, Jun Lu, Jiang Tan, Lin Li, Baiqu Huang, 2004, Human Interleukin-5 Expression is Synergistically Regulated by Histone Acetyltransferase CBP/p300 and Transcription Factors C/EBP, NF-AT and AP-1. Cytokine 27:93-100 (SCI收錄)
Haijing Sun, Jun Lu, Liang Wei, Xiuli Wang, Xin Xu, Mei Dong, Baiqu Huang, 2004, Histone acetyltransferase activity of p300 enhances the activation of IL-12 p40 promoter. Molecular Immunology 41:1241-1246 (SCI收錄)
Xiaojuan Zhu, Xianlu Zeng , Baiqu Huang, Shui Hao , 2004, Actin is closely associated with RNA polymerase II and involved in activation of gene transcription. Biochemical and Biophysical Research Communications 321: 623-630(SCI收錄)
Zhaoxia Song, Xianlu Zeng, Min Wang, Wenguang Liu, Baiqu Huang, Shui Hao, 2004, Unpolymerized nuclear actin is involved in the activation of CSF-1 gene transcription. Cell Biology International 28:511-516(SCI收錄)
Dan TAO, Jun LU, Hui SUN, Yan-Mei ZHAO, Zhi-Gen YUAN, Xiao-Xue LI, and Bai-Qu HUANG, 2004, Trichrostatin A Extends the Lifespan of Drosophila melanogaster by Elevating hsp22 Expression. Acta Biochemica et Biophysica Sinica 36(9):618-622 (SCIE收錄)
SHAO Yangguang, ZHANG Guoping, LU Jun & HUANG Baiqu , 2004, The structure and functions of transcriptional coactivators p300/CBP and their roles in regulation of interleukin gene expression. Chinese Science Bulletin 49(24):2555-2562 (SCI收錄)
2003年:
Tao Wei, Huang Baiqu, Liu Chunxiang and Zhai Zhonghe, 2003, In situ visualization of rDNA arrangement and its relationship with subnucleolar structural regions in Allium sativum cell nucleolus. Journal of Cell Science 116 (6):1117-1124 (SCI收錄)
2002年:
Chen Ting, Sun Hui, Lu Jun, Zhao Yanmei, Tao Dan, Li Xiaoxue and Huang Baiqu, 2002, Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster. Archives of Biochemistry and Biophysics 408:171-176 (SCI收錄)
Dong Yuzhu, Liu Zhenlan, Liu Bao, Bu Xiuling, He Mengyuan, Huang Baiqu and Hao Shui, 2002, Microdissection of individual chromosomes of Thinopyrum intermedium and isolation of molecular markers that are useful in detecting Th. intermedium chromatin introgressed into wheat. Cereal Research Communications 30: 253-260(SCI收錄)
著作:
黃百渠,馬煒梁 主編,2001,《高等師範教育面向21世紀教學內容和課程體系改革成果叢書》,生物學分卷,北京師範大學 出版社
近年來主持完成的鑒定成果:
1.2001年 基因工程生產α-乙醯乳酸脫羧酶中試工藝的研究。吉林省科技廳,吉科鑒字[2000]第234號
3.1997年 基因工程生產α-乙醯乳酸脫羧酶的實驗室研製。吉科鑒字[1997]第109號
4 . 2006年 中藥有效成分的篩選、配伍理論的物質基礎及中藥化學組學研究。吉林省科技廳,鑒字[2006]第179號
5 . 2009年 禽流感快速檢測技術建立及H5、H7亞型禽流感二價基因工程疫苗的研製。教育部科學技術研究重大項目結題驗收,教育部科技司,教技司便[2009]51號。
1. 應用染色體工程把天藍冰草有重要育種價值的基因轉移給小麥。1997,國家自然科學獎三等獎(排名第三)
2.用染色體工程把天藍冰草有重要育種價值的基因轉移給小麥的研究。1996,國家教委科技進步獎一等獎(排名第三)
3.植物細胞生物學和遺傳學高質量研究生的培養。1996,吉林省高等教學成果獎一等獎(排名第三)
4. 高等植物體細胞胚胎髮生和機理研究。1996,吉林省教委科技進步獎一等獎(排名第一)
6.高等植物體細胞胚胎髮生誘導的調控機理研究。1998,教育部科技進步二等獎(排名第一)
7.單子葉植物體外形態發生的激素調節和機理。2001,中國高校科學技術二等獎(排名第二)
8. 立足東北輻射全國的新型生物學人才培養基地的建設。2005,吉林省高等教育省級教學成果特等獎(排名第二)
9. 組蛋白修飾在細胞重大生命活動中的作用及機制研究。2010,中國高校自然科學一等獎(排名第一)